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Figure 2

ID: ZDB-IMAGE-201116-12
Publication: Whittle et al., 2020 - MYH3-associated distal arthrogryposis zebrafish model is normalized with para-aminoblebbistatin
All Figures: Figures for Whittle et al., 2020

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Figure Caption

Figure 2 Embryonic phenotypes of <italic>smyhc1</italic> mutants

Morphologies of smyhc1^+/+, smyhc1^−/+, and smyhc1^−/− embryos are grossly normal at 2 days postfertilization (dpf), despite complete paralysis of smyhc1^−/− embryos. In contrast, the smyhc1^R673H/+ embryos have notochord kinks in larval stages (arrow head), while smyhc1^R673H/R673H embryos have much more severe notochord kinks that compress and distort the body axis (arrow heads). The smyhc1^R673H/− embryos completely phenocopy smyhc1^R673H/R673H embryos.

Quantification of smyhc1^R673H embryonic phenotypes at 2 dpf. Representative examples of fish in each of the four phenotypic groups (normal, mild, moderate, and severe) are shown in Fig EV3.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.