ZFIN Image: Esa et al., 2020, Figure 4

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Figure 4

Inhibition of VEC and LEC proliferation and adhesion induced by the inhibition of MetAp2. (A) MetAp2 inhibition impairs the ability of both cell lines to proliferate. Cells were treated with different concentrations of TNP-470 for 72 h, after which an MTT assay was conducted to quantify their proliferation. A dose-dependent reduction was observed. *** p < 0.005, compared with the control of the same cells. n = 5. (B) HMVEC-dLyAd cells were stained with DiO and treated with TNP-470; they showed a significant decrease in their ability to adhere. The relative fluorescent cell population was quantified using the Synergy HT multi-mode microplate reader. n = 4. ** p <0.01, *** p < 0.001. The results are presented as mean ± SEM.

Acknowledgments

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