ZFIN Image: Esa et al., 2020, Figure 3

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Figure 3

MetAp2 inhibition affects the activity and expression of MetAp2 in LECs. (A) The addition of 10 μM TNP-470 treatment inhibits the enzymatic activity of MetAp2 by 23% over the course of 2 h, n = 2. (B) HMVEC-dLyAd cells were treated with 0, 0.1, 1 and 5 μM of TNP-470, and the MetAp2 mRNA levels were measured after 4 h of incubation using qRT-PCR. The inhibition of MetAp2 reduced the MetAp2 mRNA expression levels to 64%, 70% and 80%, respectively. n = 3. *** p < 0.001.

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