ZFIN Image: Esa et al., 2020, Figure 7

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Figure Caption

Figure 7

MetAp2 inhibition suppresses the growth of murine melanoma tumors. C57/BL6J mice were injected S.C. with B16/F10 cells, overexpressing VEGF-C (1.5 × 10⁶ cells/tumor). The mice were divided into two groups, untreated and treated with TNP-470 (30 mg/kg q.o.d). n = 8–10. (A) The tumor volume after 12 days of treatment with TNP-470 was significantly lower (2.3-fold) when compared with the untreated group. *** p < 0.005. (B) Representative images of tumors extracted from the untreated and treated groups after 12 days of TNP-470 treatment. (C) The mean weight of the tumors extracted from the untreated and treated mice following 12 days of TNP-470 treatment. n = 8. *** p < 0.005. (D) Immunofluorescent staining for MetAp2 (red), LYVE1 (green) and DAPI (blue) shows lymphatic structures (white arrows). The results are presented as mean ± SEM. Scale bar = 100 μm.

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