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Fig. 2

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Publication: Ding et al., 2020 - Integrative systems and functional analyses reveal a role of dopaminergic signaling in myelin pathogenesis
All Figures: Figures for Ding et al., 2020

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Fig. 2

Networks between DS and other literature-curated (oLC) genes in MS. a, b in the high-confidence human interactome database. a Number of protein–protein interactions (PPIs) between DS and oLS (Line) and 1000 randomized networks, revealing high levels of interaction between DS and oLS. b Size of the largest connected component (LCC) between DS and oLS (Line) and 1000 randomized networks, revealing a larger subnetwork between DS and oLS. c, d In the Pathway Commons database. Number of protein–protein interactions (PPIs) between DS and oLS (Line) and 1000 randomized networks with the DS gene set as upstream (c) or downstream (d). e Gene interaction between DS and oLC genes in MS. Yellow nodes-DS genes; Grey nodes-oLC genes. Edges represent their interaction

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