Gene
drl
- ID
- ZDB-GENE-991213-3
- Name
- draculin
- Symbol
- drl Nomenclature History
- Previous Names
-
- cb253 (1)
- dra
- zgc:109857
- zgc:136538
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Acts upstream of or within gastrulation with mouth forming second. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; hematopoietic cell; hematopoietic system; hypoblast; and mesoderm.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb253 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kobayashi et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kz2 | unknown | Unknown | Unknown | CRISPR | |
| la010687Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-drl,drll.1,drll.2 | (2) | |
| CRISPR2-drl | Prummel et al., 2019 | |
| CRISPR3-drl,drll.2 | Prummel et al., 2019 | |
| MO1-drl | N/A | Sumanas et al., 2005 |
| MO2-drl,drll.1,drll.2 | N/A | (2) |
| MO3-drl,drll.1,drll.2 | N/A | (2) |
| MO4-drl,drll.1,drll.2 | N/A | Karampelias et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger protein, C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:Q9W747 | InterPro | 411 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.4drl:EGFP) |
|
| Zebrafish Nomenclature Committee | ||
| Tg(-0.9drl:EGFP) |
|
| Zebrafish Nomenclature Committee | ||
| Tg(+2.0drl:Cre-ERT2) |
|
| Zebrafish Nomenclature Committee | ||
| Tg(+2.0drl:EGFP) |
|
| Zebrafish Nomenclature Committee | ||
| Tg(+2.5drl:EGFP) |
|
| Zebrafish Nomenclature Committee | ||
| Tg(-6.3drl:mCherry) |
|
| 1 | (9) | |
| Tg(-6.35drl:Cre-ERT2,cryaa:Venus) |
|
| 1 | (16) | |
| Tg(-6.35drl:Cre-ERT2,myl7:EGFP) |
|
| 1 | (3) | |
| Tg(-6.35drl:EGFP) |
|
| 1 | (12) | |
| TgBAC(drl:NLS-mCherry) |
|
| 1 | Nakajima et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-261J4 | ZFIN Curated Data | |
| Encodes | EST | cb253 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:109857 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136538 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130977 (1) | 1861 nt | ||
| Genomic | GenBank:AL935280 (1) | 221563 nt | ||
| Polypeptide | UniProtKB:Q9W747 (1) | 411 aa |
No data available
- Wei, X., Wang, W., Yin, Q., Li, H., Ahmed, A., Ullah, R., Li, W., Jing, L. (2024) In Vivo Chemical Screening in Zebrafish Embryos Identified FDA-Approved Drugs That Induce Differentiation of Acute Myeloid Leukemia Cells. International Journal of Molecular Sciences. 25(14):
- Nakajima, H., Ishikawa, H., Yamamoto, T., Chiba, A., Fukui, H., Sako, K., Fukumoto, M., Mattonet, K., Kwon, H.B., Hui, S.P., Dobreva, G.D., Kikuchi, K., Helker, C.S.M., Stainier, D.Y.R., Mochizuki, N. (2023) Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Developmental Cell. 58(3):224-238.e7
- Suzuki, H., Ogawa, T., Fujita, S., Sone, R., Kawahara, A. (2023) Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis. Scientific Reports. 13:1227912279
- Huang, M., Ahmed, A., Wang, W., Wang, X., Ma, C., Jiang, H., Li, W., Jing, L. (2022) Negative Elongation Factor (NELF) Inhibits Premature Granulocytic Development in Zebrafish. International Journal of Molecular Sciences. 23(7):
- Karampelias, C., Watt, K., Mattsson, C.L., Ruiz, Á.F., Rezanejad, H., Mi, J., Liu, X., Chu, L., Locasale, J.W., Korbutt, G.S., Rovira, M., Larsson, O., Andersson, O. (2022) MNK2 deficiency potentiates β-cell regeneration via translational regulation. Nature Chemical Biology. 18(9):942-953
- Wang, W., Li, H., Huang, M., Wang, X., Li, W., Qian, X., Jing, L. (2022) Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance. Open Biology. 12:220172
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- García-Castillo, J., Alcaraz-Pérez, F., Martínez-Balsalobre, E., García-Moreno, D., Rossmann, M.P., Fernández-Lajarín, M., Bernabé-García, M., Pérez-Oliva, A.B., Rodríguez-Cortez, V.C., Bueno, C., Adatto, I., Agarwal, S., Menéndez, P., Zon, L.I., Mulero, V., Cayuela, M.L. (2021) Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 118(32):
- Liu, K.C., Villasenor, A., Bertuzzi, M., Schmitner, N., Radros, N., Rautio, L., Mattonet, K., Matsuoka, R.L., Reischauer, S., Stainier, D.Y., Andersson, O. (2021) Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification. eLIFE. 10:
- Ulloa, B.A., Habbsa, S.S., Potts, K.S., Lewis, A., McKinstry, M., Payne, S.G., Flores, J.C., Nizhnik, A., Feliz Norberto, M., Mosimann, C., Bowman, T.V. (2021) Definitive hematopoietic stem cells minimally contribute to embryonic hematopoiesis. Cell Reports. 36:109703
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