Gene

sema3ab

ID
ZDB-GENE-991209-6
Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
Symbol
sema3ab Nomenclature History
Previous Names
  • sema3a2 (1)
  • semaZ1b
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Acts upstream of or within branching involved in blood vessel morphogenesis; branching morphogenesis of a nerve; and motor neuron axon guidance. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon; extracellular space; and glutamatergic synapse. Is expressed in brain; myotome; optic cup; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia. Orthologous to human SEMA3A (semaphorin 3A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa6502Allele with one point mutationUnknownPremature StopENU
sa13929Allele with one point mutationUnknownPremature StopENU
sa23237Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With sema3ab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypogonadotropic hypogonadism 16 with or without anosmia Alliance {Hypogonadotropic hypogonadism 16 with or without anosmia} 614897
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Associated With sema3ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001627 Sema domain
Domain IPR003599 Immunoglobulin domain subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR016201 PSI domain
Family IPR027231 Semaphorin
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Domain Details Per Protein
Protein Additional Resources Length Immunoglobulin domain subtype Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold PSI domain Sema domain Sema domain superfamily Semaphorin WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q9W686 InterPro 778
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 18
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sema3ab-201 (1) Ensembl 2,652 nt
mRNA sema3ab-202 (1) Ensembl 2,704 nt
mRNA sema3ab-203 (1) Ensembl 2,556 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-120M13ZFIN Curated Data
Contained inBACCH211-215B21ZFIN Curated Data
EncodesESTal918132ZFIN Curated Data
EncodescDNAcssl:d406Bushell et al., 2007
EncodescDNAMGC:194565ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSEMA3A7
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
MouseSema3a5
Amino acid sequence comparison (1)
Phylogenetic tree (1)
Conserved genome location (synteny) (1)
Citations
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