Gene

sema3aa

ID
ZDB-GENE-991209-3
Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa
Symbol
sema3aa Nomenclature History
Previous Names
  • sem1a (1)
  • sema3A1 (1)
  • sema3a1 (1)
  • semaZ1a
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Acts upstream of or within blood vessel morphogenesis and nervous system development. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon; extracellular space; and glutamatergic synapse. Is expressed in several structures, including anterior neural rod; brain; head; immature eye; and muscle. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia. Orthologous to human SEMA3A (semaphorin 3A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
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Sequence Targeting Reagents
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Human Disease
Associated With sema3aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypogonadotropic hypogonadism 16 with or without anosmia Alliance {Hypogonadotropic hypogonadism 16 with or without anosmia} 614897
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Associated With sema3aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001627 Sema domain
Domain IPR003599 Immunoglobulin domain subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR016201 PSI domain
Family IPR027231 Semaphorin
1 - 5 of 9 Show all
Domain Details Per Protein
Protein Additional Resources Length Immunoglobulin domain subtype Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold PSI domain Sema domain Sema domain superfamily Semaphorin WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q9W7J1 InterPro 860
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 4
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sema3aa-201 (1) Ensembl 4,617 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(hsp70l:EGFP-sema3aa-6xMYC)
  • Danio rerio
2 (6)
Tg(myl7:sema3aa)
  • sema3aa
  • Danio rerio
1 (2)
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Marker Relationships
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSEMA3A7
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
MouseSema3a5
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Phylogenetic tree (1)
Citations
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