Gene
ctnna1
- ID
- ZDB-GENE-991207-24
- Name
- catenin (cadherin-associated protein), alpha 1
- Symbol
- ctnna1 Nomenclature History
- Previous Names
-
- ctnna
- dan[a]E
- [a]E-catenin (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables actin filament binding activity and cadherin binding activity. Involved in adherens junction maintenance and chordate embryonic development. Acts upstream of or within tissue homeostasis. Located in adherens junction; cell cortex; and microvillus. Part of catenin complex. Is expressed in DEL. Human ortholog(s) of this gene implicated in patterned macular dystrophy 2. Orthologous to human CTNNA1 (catenin alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76830 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ct3aGt | Transgenic insertion | Unknown | Unknown | DNA | |
hu10414 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
la014591Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa24534 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa39460 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-ctnna1 | N/A | Schepis et al., 2012 |
MO2-ctnna1 | N/A | (3) |
TALEN1-ctnna1 | Han et al., 2016 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
patterned macular dystrophy 2 | Alliance | Macular dystrophy, patterned, 2 | 608970 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Alpha-catenin | Alpha-catenin/vinculin-like superfamily | Vinculin/alpha-catenin | Vinculin, conserved site |
---|---|---|---|---|---|---|
UniProtKB:Q9PVF8 | InterPro | 907 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
ctnna1-201
(1)
|
Ensembl | 3,734 nt |
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Interactions and Pathways
No data available
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(kdrl:ctnna-EGFP) |
|
| 1 | (4) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-214P17 | ZFIN Curated Data | |
Contained in | BAC | CH211-271O13 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-36H4 | ZFIN Curated Data | |
Contained in | Fosmid | ZFOS-887A5 | ZFIN Curated Data | |
Encodes | cDNA | MGC:76830 | ZFIN Curated Data | |
Encodes | cDNA | MGC:175043 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131456 (1) | 3750 nt | ||
Genomic | GenBank:CU681852 (1) | 198109 nt | ||
Polypeptide | UniProtKB:Q9PVF8 (1) | 907 aa |
- Brown, T.L., Horton, E.C., Craig, E.W., Goo, C.E.A., Black, E.C., Hewitt, M.N., Yee, N.G., Fan, E.T., Raible, D.W., Rasmussen, J.P. (2023) Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells. eLIFE. 12:
- Boutillon, A., Escot, S., Elouin, A., Jahn, D., González-Tirado, S., Starruß, J., Brusch, L., David, N.B. (2022) Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception. Developmental Cell. 57(12):1529-1544.e5
- Slováková, J., Sikora, M., Arslan, F.N., Caballero-Mancebo, S., Krens, S.F.G., Kaufmann, W.A., Merrin, J., Heisenberg, C.P. (2022) Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 119(8):
- Yamaguchi, N., Zhang, Z., Schneider, T., Wang, B., Panozzo, D., Knaut, H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature cell biology. 24:194-204
- Sharma, S., Kumar, M., Kumar, J., Srivastava, N., Hussain, M.A., Shelly, A., Mazumder, S. (2021) M. fortuitum-induced CNS-pathology: Deciphering the role of canonical Wnt signaling, blood brain barrier components and cytokines. Developmental and comparative immunology. 122:104111
- Colak-Champollion, T., Lan, L., Jadhav, A.R., Yamaguchi, N., Venkiteswaran, G., Patel, H., Cammer, M., Meier-Schellersheim, M., Knaut, H. (2019) Cadherin-Mediated Cell Coupling Coordinates Chemokine Sensing across Collectively Migrating Cells. Current biology : CB. 29:2570-2579.e7
- Espenschied, S.T., Cronan, M.R., Matty, M.A., Mueller, O., Redinbo, M.R., Tobin, D.M., Rawls, J.F. (2019) Epithelial delamination is protective during pharmaceutical-induced enteropathy. Proceedings of the National Academy of Sciences of the United States of America. 116(34):16961-16970
- Jiang, N., Rasmussen, J.P., Clanton, J.A., Rosenberg, M.F., Luedke, K.P., Cronan, M.R., Parker, E.D., Kim, H.J., Vaughan, J.C., Sagasti, A., Parrish, J.Z. (2019) A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. eLIFE. 8:
- Rödel, C.J., Otten, C., Donat, S., Lourenco, M., Fischer, D., Kuropka, B., Paolini, A., Freund, C., Abdelilah-Seyfried, S. (2019) Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. Circulation research. 125(10):e43-e54
- Yamaguchi, N., Colak-Champollion, T., Knaut, H. (2019) zGrad is a nanobody-based degron system that inactivates proteins in zebrafish. eLIFE. 8:
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