Gene
nog2
- ID
- ZDB-GENE-991206-14
- Name
- noggin 2
- Symbol
- nog2 Nomenclature History
- Previous Names
-
- zNog2
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Acts upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; notochord; segmental plate; spinal cord neural tube; and tail bud.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Amorim et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-nog2 | Amorim et al., 2020 | |
MO1-nog2 | N/A | Amorim et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cystine-knot cytokine | Noggin |
---|---|---|---|---|
UniProtKB:Q9W740 | InterPro | 212 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-383P20 | ZFIN Curated Data | |
Encodes | cDNA | MGC:65736 | ZFIN Curated Data | |
Encodes | cDNA | MGC:85600 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_130992 (1) | 2022 nt | ||
Genomic | GenBank:FP236632 (2) | 95187 nt | ||
Polypeptide | UniProtKB:Q9W740 (1) | 212 aa |
No data available
- Bulk, J., Kyrychenko, V., Rensinghoff, P.M., Ghaderi Ardekani, Z., Heermann, S. (2023) Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish. International Journal of Molecular Sciences. 24(9):
- Knickmeyer, M.D., Mateo, J.L., Heermann, S. (2021) BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Amorim, J.P., Gali-Macedo, A., Marcelino, H., Bordeira-Carriço, R., Naranjo, S., Rivero-Gil, S., Teixeira, J., Galhardo, M., Marques, J., Bessa, J. (2020) A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates. Cell Reports. 32:107862
- Huang, V., Butler, A.A., Lubin, F.D. (2019) Telencephalon transcriptome analysis of chronically stressed adult zebrafish. Scientific Reports. 9:1379
- Wagner, D.E., Weinreb, C., Collins, Z.M., Briggs, J.A., Megason, S.G., Klein, A.M. (2018) Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science (New York, N.Y.). 360(6392):981-987
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Crespo, D., Assis, L.H., Furmanek, T., Bogerd, J., Schulz, R.W. (2016) Expression profiling identifies Sertoli and Leydig cell genes as Fsh targets in adult zebrafish testis. Molecular and Cellular Endocrinology. 437:237-251
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Merkes, C., Turkalo, T.K., Wilder, N., Park, H., Wenger, L.W., Lewin, S.J., Azuma, M. (2015) Ewing Sarcoma Ewsa Protein Regulates Chondrogenesis of Meckel's Cartilage through Modulation of Sox9 in Zebrafish. PLoS One. 10:e0116627
- Messina, A., Incitti, T., Bozza, A., Bozzi, Y., Casarosa, S. (2014) Noggin Expression in the Adult Retina Suggests a Conserved Role during Vertebrate Evolution. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 62(7):532-540
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