Gene
irx3a
- ID
- ZDB-GENE-991119-5
- Name
- iroquois homeobox 3a
- Symbol
- irx3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within endocrine pancreas development and gastrulation. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; germ ring; hindbrain neural keel; nervous system; and neural rod. Orthologous to human IRX3 (iroquois homeobox 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 45 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109805 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ragvin et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-irx3a | Farmer et al., 2021 | |
| CRISPR2-irx3a | Kamimoto et al., 2023 | |
| CRISPR3-irx3a | Kamimoto et al., 2023 | |
| MO1-irx3a | N/A | (3) |
| MO2-irx3a | N/A | Ragvin et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Iroquois-class homeodomain protein | KN homeodomain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90Z68 | InterPro | 454 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(E200-irx3a:EGFP) |
|
| 1 | (2) | |
| Tg(Z176-irx3a:EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-103G18 | ZFIN Curated Data | |
| Encodes | EST | fk88a03 | (2) | |
| Encodes | EST | ibd3380 | ZFIN Curated Data | |
| Encodes | EST | fa91c03 | ZFIN Curated Data | |
| Encodes | EST | zehn0543 | ||
| Encodes | cDNA | MGC:109805 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174145 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193063 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131267 (1) | 2640 nt | ||
| Genomic | GenBank:CT030037 (1) | 203577 nt | ||
| Polypeptide | UniProtKB:Q90Z68 (1) | 454 aa |
- Karimzadeh, K., Uju, C., Zahmatkesh, A., Unniappan, S. (2024) Fat mass and obesity associated gene and homeobox transcription factor iriquois-3 mRNA profiles in the metabolic tissues of zebrafish are modulated by feeding and food deprivation. General and comparative endocrinology. 360:114621
- Kamimoto, K., Stringa, B., Hoffmann, C.M., Jindal, K., Solnica-Krezel, L., Morris, S.A. (2023) Dissecting cell identity via network inference and in silico gene perturbation. Nature. 614(7949):742-751
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Farmer, D.T., Patel, P., Choi, R., Liu, C.Y., Crump, J.G. (2021) Comprehensive series of Irx cluster mutants reveals diverse roles in facial cartilage development. Development (Cambridge, England). 148(16)
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Scott, K., O'Rourke, R., Winkler, C.C., Kearns, C.A., Appel, B. (2021) Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Developmental Biology. 479:37-50
- Iwanami, N., Takeshita, K., Lawir, D.F., Suetake, I., Tajima, S., Sikora, K., Trancoso, I., ÓMeara, C., Siamishi, I., Takahama, Y., Furutani-Seiki, M., Kondoh, H., Yonezawa, Y., Schorpp, M., Boehm, T. (2020) Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1. iScience. 23:101260
- Ramakrishnan Varadarajan, A., Mopuri, R., Streelman, J.T., McGrath, P.T. (2018) Genome-wide protein phylogenies for four African cichlid species. BMC Evolutionary Biology. 18:1
- Rinkwitz, S., Geng, F., Manning, E., Suster, M., Kawakami, K., Becker, T.S. (2015) BAC transgenic zebrafish reveal hypothalamic enhancer activity around obesity associated SNP rs9939609 within the human FTO gene. Genesis (New York, N.Y. : 2000). 53(10):640-51
- Bessa, J., Luengo, M., Rivero-Gil, S., Ariza-Cosano, A., Maia, A.H., Ruiz-Ruano, F.J., Caballero, P., Naranjo, S., Carvajal, J.J., and Gómez-Skarmeta, J.L. (2014) A mobile insulator system to detect and disrupt cis-regulatory landscapes in vertebrates. Genome research. 24(3):487-95
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