Gene
tyr
- ID
- ZDB-GENE-991026-3
- Name
- tyrosinase
- Symbol
- tyr Nomenclature History
- Previous Names
-
- oca1
- sandy
- sdy
- tyra (1)
- zgc:109705
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables catechol oxidase activity. Acts upstream of or within several processes, including dopamine biosynthetic process from tyrosine; iridophore differentiation; and melanosome organization. Predicted to be located in melanosome membrane. Predicted to be active in melanosome. Is expressed in several structures, including eye; male organism; melanoblast; neural crest; and presumptive retinal pigmented epithelium. Used to study color blindness and oculocutaneous albinism. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 32 figures from 18 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
oculocutaneous albinism type IA | Alliance | Albinism, oculocutaneous, type IA | 203100 |
oculocutaneous albinism type IB | Alliance | Albinism, oculocutaneous, type IB | 606952 |
[Skin/hair/eye pigmentation 3, blue/green eyes] | 601800 | ||
[Skin/hair/eye pigmentation 3, light/dark/freckling skin] | 601800 | ||
{Melanoma, cutaneous malignant, susceptibility to, 8} | 601800 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
oculocutaneous albinism | tyrck112a/ck112a | standard conditions | Park et al., 2016 |
color blindness | tyrck112a/ck112a | standard conditions | Park et al., 2016 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Di-copper centre-containing domain superfamily | Tyrosinase and Hemocyanin | Tyrosinase copper-binding domain |
---|---|---|---|---|---|
UniProtKB:A0A8M1PAD4 | InterPro | 534 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Encodes | EST | aj250302 | Camp et al., 2001 | |
Has Artifact | cDNA | MGC:109705 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131013 (1) | 1955 nt | ||
Genomic | GenBank:CU856545 (1) | 111121 nt | ||
Polypeptide | UniProtKB:A0A8M1PAD4 (1) | 534 aa |
- Moreno-Sánchez, I., Hernández-Huertas, L., Nahón-Cano, D., Martínez-García, P.M., Treichel, A.J., Gómez-Marin, C., Tomás-Gallardo, L., da Silva Pescador, G., Kushawah, G., Egidy, R., Perera, A., Díaz-Moscoso, A., Cano-Ruiz, A., Walker, J.A., Muñoz, M.J., Holden, K., Galcerán, J., Nieto, M.Á., Bazzini, A.A., Moreno-Mateos, M.A. (2025) Enhanced RNA-targeting CRISPR-Cas technology in zebrafish. Nature communications. 16:25912591
- Raas, Q., Haouy, G., de Calbiac, H., Pasho, E., Marian, A., Guerrera, I.C., Rosello, M., Oeckl, P., Del Bene, F., Catanese, A., Ciura, S., Kabashi, E. (2025) TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models. Cell death discovery. 11:9898
- Wusiman, Z., Zhang, A.M., Zhang, S.S., Zhao, P.P., Kang, Y.T., Zhang, Y., Li, Z.J., Huo, S.X. (2025) Galangin ameliorates PTU-induced vitiligo in zebrafish and B16F10 cells by increasing melanogenesis through activation of the p38/JNK MAPK pathway. Frontiers in pharmacology. 16:15210971521097
- Zheng, S., Liu, Y., Xia, X., Xiao, J., Ma, H., Yuan, X., Zhang, Y., Chen, Z., Peng, G., Li, W., Fei, J.F., Liu, Y. (2025) Sequence Context-Agnostic TadA-Derived Cytosine Base Editors for Genome-Wide Editing in Zebrafish. Advanced science (Weinheim, Baden-Wurttemberg, Germany). :e2411478e2411478
- Krueger, C.J., Dai, Z., Zhu, C., Zhang, B. (2024) Heritable CRISPR Mutagenesis of Essential Maternal Effect Genes as a Simple Tool for Sustained Population Suppression of Invasive Species in a Zebrafish Model. Zebrafish. 21(4):279-286
- Locubiche, S., Ordóñez, V., Abad, E., Scotto di Mase, M., Di Donato, V., De Santis, F. (2024) A Zebrafish-Based Platform for High-Throughput Epilepsy Modeling and Drug Screening in F0. International Journal of Molecular Sciences. 25(5):
- Ma, J., Zhang, W., Rahimialiabadi, S., Ganesh, N.U., Sun, Z., Parvez, S., Peterson, R.T., Yeh, J.J. (2024) Instantaneous visual genotyping and facile site-specific transgenesis via CRISPR-Cas9 and phiC31 integrase. Biology Open. 13(9):
- Mori, Y., Smith, S., Wang, J., Eliora, N., Heikes, K.L., Munjal, A. (2024) Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis. Development (Cambridge, England). 152(1):
- Noonan, H.R., Thornock, A.M., Barbano, J., Xifaras, M.E., Baron, C.S., Yang, S., Koczirka, K., McConnell, A.M., Zon, L.I. (2024) A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma. eLIFE. 13:
- Ujiie, H., Nishiya, N., Yamamoto, A., Takada, T., Onodera, M., Sasaki, A., Oikawa, T. (2024) Dexamethasone reduces cisplatin-induced hair cell damage by inducing cisplatin resistance through metallothionein-2. Cancer Chemotherapy and Pharmacology. 94(4):561-569
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