Gene
skib
- ID
- ZDB-GENE-990715-10
- Name
- v-ski avian sarcoma viral oncogene homolog b
- Symbol
- skib Nomenclature History
- Previous Names
-
- skiB
- fc17g02
- wu:fc17g02 (1)
- wu:fk79g04
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Acts upstream of or within cartilage development; dorsal/ventral pattern formation; and heart looping. Located in nucleus. Is expressed in central nervous system and telencephalon. Used to study craniosynostosis. Orthologous to human SKI (SKI proto-oncogene).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la010625Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la010824Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la011985Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la017804Tg | Transgenic insertion | Unknown | Unknown | DNA | |
nk15aEt | Transgenic insertion | Unknown | Unknown | DNA | |
sa9865 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa41845 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 7 of 7
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-skib | N/A | (2) |
MO2-skib | N/A | Cui et al., 2001 |
1 - 2 of 2
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
craniosynostosis | Alliance | Shprintzen-Goldberg syndrome | 182212 |
1 - 1 of 1
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
craniosynostosis | WT + MO1-skib | standard conditions | Doyle et al., 2012 |
1 - 1 of 1
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR003380 | SKI/SNO/DAC domain |
Domain | IPR014890 | c-SKI SMAD4-binding domain |
Domain | IPR047315 | Ski oncogene-like, Dachshund-homology domain |
Family | IPR023216 | Transcription regulator SKI/SnoN |
Homologous_superfamily | IPR009061 | Putative DNA-binding domain superfamily |
1 - 5 of 7 Show all
Domain Details Per Protein
Protein | Additional Resources | Length | c-SKI SMAD4-binding domain | Putative DNA-binding domain superfamily | SAND-like domain superfamily | Ski-like, DNA-binding domain superfamily | Ski oncogene-like, Dachshund-homology domain | SKI/SNO/DAC domain | Transcription regulator SKI/SnoN |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q9YI02 | InterPro | 695 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-156A5 | ZFIN Curated Data | |
Contained in | BAC | DKEY-183J2 | ZFIN Curated Data | |
Encodes | EST | fc17g02 | ZFIN Curated Data | |
Encodes | EST | fk79g04 | ZFIN Curated Data | |
Has Artifact | EST | fc87g11 |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_130938 (1) | 3316 nt | ||
Genomic | GenBank:CR933820 (1) | 230267 nt | ||
Polypeptide | UniProtKB:Q9YI02 (1) | 695 aa |
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Doyle, A.J., Doyle, J.J., Bessling, S.L., Maragh, S., Lindsay, M.E., Schepers, D., Gillis, E., Mortier, G., Homfray, T., Sauls, K., Norris, R.A., Huso, N.D., Leahy, D., Mohr, D.W., Caulfield, M.J., Scott, A.F., Destrée, A., Hennekam, R.C., Arn, P.H., Curry, C.J., Van Laer, L., McCallion, A.S., Loeys, B.L., and Dietz, H.C. (2012) Mutations in the TGF-beta repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. Nature Genetics. 44(11):1249-1254
- Asakawa, K., Suster, M.L., Mizusawa, K., Nagayoshi, S., Kotani, T., Urasaki, A., Kishimoto, Y., Hibi, M., and Kawakami, K. (2008) Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 105(4):1255-1260
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Cui, Z., Clark, K.J., Kaufman, C.D., and Hackett, P.B. (2001) Inhibition of skiA and skiB gene expression ventralizes zebrafish embryos. Genesis (New York, N.Y. : 2000). 30(3):149-153
- Kaufman, C.D., Martinez-Rodriguez, G., and Hackett, P.B. (2000) Ectopic expression of c-ski disrupts gastrulation and neural patterning in zebrafish. Mechanisms of Development. 95(1-2):147-162
1 - 8 of 8
Show