Gene
nog3
- ID
- ZDB-GENE-990714-8
- Name
- noggin 3
- Symbol
- nog3 Nomenclature History
- Previous Names
-
- zNog3
- noggin
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including cloaca development; embryonic viscerocranium morphogenesis; and regionalization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in cartilage element; fin; head; and otic vesicle. Human ortholog(s) of this gene implicated in Huntington's disease; bone disease (multiple); cleft lip; and hyperopia. Orthologous to human NOG (noggin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu301 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ning et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| brachydactyly type B2 | Alliance | Brachydactyly, type B2 | 611377 |
| multiple synostoses syndrome 1 | Alliance | Multiple synostoses syndrome 1 | 186500 |
| proximal symphalangism 1 | Alliance | Symphalangism, proximal, 1A | 185800 |
| tarsal-carpal coalition syndrome | Alliance | Tarsal-carpal coalition syndrome | 186570 |
| Stapes ankylosis with broad thumbs and toes | 184460 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Noggin |
|---|---|---|---|---|
| UniProtKB:Q9YHV3 | InterPro | 223 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:nog3) |
|
| 1 | (28) | |
| Tg(-5.5nkx2.3:nog3-mCherry) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg(hsp70l:nog3-FLAG,myl7:NLS-mCherry) |
| 1 | Nakajima et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-199H23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-33G13 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-64D20 | ||
| Encodes | EST | eu301 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:194270 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194310 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130982 (1) | 672 nt | ||
| Genomic | GenBank:AL935268 (2) | 206438 nt | ||
| Polypeptide | UniProtKB:Q9YHV3 (1) | 223 aa |
- Nakajima, H., Ishikawa, H., Yamamoto, T., Chiba, A., Fukui, H., Sako, K., Fukumoto, M., Mattonet, K., Kwon, H.B., Hui, S.P., Dobreva, G.D., Kikuchi, K., Helker, C.S.M., Stainier, D.Y.R., Mochizuki, N. (2023) Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Developmental Cell. 58(3):224-238.e7
- Pogoda, H.M., Riedl-Quinkertz, I., Hammerschmidt, M. (2023) Direct BMP signaling to chordoblasts is required for the initiation of segmented notochord sheath mineralization in zebrafish vertebral column development. Frontiers in endocrinology. 14:11073391107339
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Knickmeyer, M.D., Mateo, J.L., Heermann, S. (2021) BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Félix, L.M., Luzio, A., Antunes, L., Coimbra, A.M., Valentim, A. (2020) Malformations and mortality in zebrafish early stages associated with elevated caspase activity after 24 h exposure to MS-222. Toxicology and applied pharmacology. 412:115385
- Mao, A., Zhang, M., Li, L., Liu, J., Ning, G., Cao, Y., Wang, Q. (2020) Pharyngeal pouches provide a niche microenvironment for arch artery progenitor specification. Development (Cambridge, England). 148(2):
- Niu, X., Subramanian, A., Hwang, T.H., Schilling, T.F., Galloway, J.L. (2020) Tendon Cell Regeneration Is Mediated by Attachment Site-Resident Progenitors and BMP Signaling. Current biology : CB. 30(17):3277-3292.e5
- Sapède, D., Chaigne, C., Blader, P., Cau, E. (2020) Functional heterogeneity in the pineal projection neurons of zebrafish. Molecular and cellular neurosciences. 103:103468
- Andrés-Delgado, L., Ernst, A., Galardi-Castilla, M., Bazaga, D., Peralta, M., Münch, J., González-Rosa, J.M., Marques, I., Tessadori, F., de la Pompa, J.L., Vermot, J., Mercader, N. (2019) Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells. Development (Cambridge, England). 146(13):
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