Gene

eya1

ID
ZDB-GENE-990712-18
Name
EYA transcriptional coactivator and phosphatase 1
Symbol
eya1 Nomenclature History
Previous Names
  • dog eared (1)
  • dog (1)
  • wu:fc13c10
  • zgc:100770
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within adenohypophysis development; otic vesicle morphogenesis; and otolith development. Predicted to be active in nucleus. Is expressed in several structures, including adenohypophyseal placode; ectoderm; head; mesoderm pectoral fin bud; and nervous system. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and branchiootorenal syndrome 1. Orthologous to human EYA1 (EYA transcriptional coactivator and phosphatase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
78 figures from 54 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
eya1_unspecifiedUnspecified AlleleUnknownUnknownnot specified
hi2933TgTransgenic insertionIntron 9UnknownDNA
la014503TgTransgenic insertionUnknownUnknownDNA
la014504TgTransgenic insertionUnknownUnknownDNA
la022847TgTransgenic insertionUnknownUnknownDNA
la028596TgTransgenic insertionUnknownUnknownDNA
sa3273Allele with one point mutationUnknownSplice SiteENU
sa10957Allele with one point mutationUnknownPremature StopENU
sa11723Allele with one point mutationUnknownPremature StopENU
t22744Allele with one point mutationUnknownPremature Stopnot specified
1 - 10 of 14
Show
Sequence Targeting Reagents
1 - 6 of 6
Show
Human Disease
Associated With eya1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
branchiootic syndrome Alliance Anterior segment anomalies with or without cataract 602588
branchiootic syndrome Alliance Branchiootic syndrome 1 602588
branchiootorenal syndrome 1 Alliance Branchiootorenal syndrome 1, with or without cataracts 113650
?Otofaciocervical syndrome 166780
1 - 4 of 4
Associated With eya1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006545 EYA domain
Domain IPR042577 EYA domain, metazoan
Family IPR028472 Protein phosphatase EYA
Homologous_superfamily IPR038102 EYA domain superfamily
1 - 4 of 4
Domain Details Per Protein
Protein Additional Resources Length EYA domain EYA domain, metazoan EYA domain superfamily Protein phosphatase EYA
UniProtKB:A0A8M3AZ17 InterPro 592
UniProtKB:A0A8M2B9H5 InterPro 586
UniProtKB:A0A8M3AP55 InterPro 613
UniProtKB:A0A8M6YVK2 InterPro 614
UniProtKB:Q6DBY3 InterPro 587
1 - 5 of 6 Show all
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 24
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA eya1-201 (1) Ensembl 2,179 nt
mRNA eya1-202 (1) Ensembl 4,414 nt
mRNA eya1-203 (1) Ensembl 2,229 nt
mRNA eya1-204 (1) Ensembl 4,447 nt
mRNA eya1-206 (1) Ensembl 723 nt
1 - 5 of 7 Show all
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-19O24ZFIN Curated Data
Contained inBACDKEY-94E15ZFIN Curated Data
Contained inBACDKEY-110O13ZFIN Curated Data
EncodesESTfc13c10ZFIN Curated Data
EncodescDNAMGC:100770ZFIN Curated Data
EncodescDNAMGC:173810ZFIN Curated Data
1 - 6 of 6
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanEYA18
Amino acid sequence comparison (3)
Conserved genome location (synteny) (1)
MouseEya11
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
1 - 10 of 98
Show