Gene
eya1
- ID
- ZDB-GENE-990712-18
- Name
- EYA transcriptional coactivator and phosphatase 1
- Symbol
- eya1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within adenohypophysis development; otic vesicle morphogenesis; and otolith development. Predicted to be active in nucleus. Is expressed in several structures, including adenohypophyseal placode; ectoderm; head; mesoderm pectoral fin bud; and nervous system. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and branchiootorenal syndrome 1. Orthologous to human EYA1 (EYA transcriptional coactivator and phosphatase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 78 figures from 54 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
eya1_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
hi2933Tg | Transgenic insertion | Intron 9 | Unknown | DNA | |
la014503Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la014504Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la022847Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028596Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa3273 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa10957 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa11723 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
t22744 | Allele with one point mutation | Unknown | Premature Stop | not specified |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-eya1 | Borges et al., 2024 | |
CRISPR2-eya1 | Borges et al., 2024 | |
CRISPR3-eya1 | Borges et al., 2024 | |
CRISPR4-eya1 | Borges et al., 2024 | |
MO1-eya1 | N/A | (3) |
MO2-eya1 | N/A | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
branchiootic syndrome | Alliance | Anterior segment anomalies with or without cataract | 602588 |
branchiootic syndrome | Alliance | Branchiootic syndrome 1 | 602588 |
branchiootorenal syndrome 1 | Alliance | Branchiootorenal syndrome 1, with or without cataracts | 113650 |
?Otofaciocervical syndrome | 166780 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | EYA domain | EYA domain, metazoan | EYA domain superfamily | Protein phosphatase EYA |
---|---|---|---|---|---|---|
UniProtKB:A0A8M3AZ17 | InterPro | 592 | ||||
UniProtKB:A0A8M2B9H5 | InterPro | 586 | ||||
UniProtKB:A0A8M3AP55 | InterPro | 613 | ||||
UniProtKB:A0A8M6YVK2 | InterPro | 614 | ||||
UniProtKB:Q6DBY3 | InterPro | 587 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-19O24 | ZFIN Curated Data | |
Contained in | BAC | DKEY-94E15 | ZFIN Curated Data | |
Contained in | BAC | DKEY-110O13 | ZFIN Curated Data | |
Encodes | EST | fc13c10 | ZFIN Curated Data | |
Encodes | cDNA | MGC:100770 | ZFIN Curated Data | |
Encodes | cDNA | MGC:173810 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131193 (1) | 4438 nt | ||
Genomic | GenBank:BX510326 (1) | 239398 nt | ||
Polypeptide | UniProtKB:A0A8M6YVK2 (1) | 614 aa |
- Borges, A., Pinto-Teixeira, F., Wibowo, I., Pogoda, H.M., Hammerschmidt, M., Kawakami, K., López-Schier, H., Miranda-Rodríguez, J.R. (2024) Incoherent collective cell chemotaxis underlies organ dysmorphia in a model of branchio-oto-renal syndrome. microPublication. Biology. 2024:
- Wang, F., Zhang, R., Jian, J., Sun, Y., Li, Q. (2024) Identification and functional study of enhancers of EYA1, the causative gene of branchio-oto-renal syndrome. Developmental neuroscience. 46(5):333-340
- Zhao, Y., Wang, Z., Xu, M., Qian, F., Wei, G., Liu, D. (2024) The Glutamine Synthetases Are Required for Sensory Hair Cell Formation and Auditory Function in Zebrafish. International Journal of Molecular Sciences. 25(21):
- Sun, L., Ping, L., Gao, R., Zhang, B., Chen, X. (2023) lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway. Genes. 14(7):
- Wang, C., Wang, X., Zheng, H., Yao, J., Xiang, Y., Liu, D. (2023) The ndrg2 Gene Regulates Hair Cell Morphogenesis and Auditory Function during Zebrafish Development. International Journal of Molecular Sciences. 24(12):
- Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668
- Tang, D., Zheng, S., Zheng, Z., Liu, C., Zhang, J., Yan, R., Wu, C., Zuo, N., Wu, L., Xu, H., Liu, S., He, Y. (2022) Dnmt1 is required for the development of auditory organs via cell cycle arrest and Fgf signalling. Cell Proliferation. 55(5):e13225
- Wei, G., Zhang, X., Cai, C., Sheng, J., Xu, M., Wang, C., Gu, Q., Guo, C., Chen, F., Liu, D., Qian, F. (2022) Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway. Frontiers in Cellular Neuroscience. 16:840143
- Gong, J., Qian, P., Hu, Y., Guo, C., Wei, G., Wang, C., Cai, C., Wang, H., Liu, D. (2021) Claudin h Is Essential for Hair Cell Morphogenesis and Auditory Function in Zebrafish. Frontiers in cell and developmental biology. 9:663995
- Hu, S.Q., Xu, H.M., Qian, F., Chen, C.S., Wang, X., Liu, D., Cheng, L. (2021) Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis. Developmental Neurobiology. 82(1):88-97
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