Gene
otpb
- ID
- ZDB-GENE-990708-7
- Name
- orthopedia homeobox b
- Symbol
- otpb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Involved in myelination. Acts upstream of or within forebrain neuron development; hypothalamus development; and mammillary body development. Predicted to be located in nucleus. Is expressed in several structures, including brain; gonad; neural keel; neural plate; and neurons. Orthologous to human OTP (orthopedia homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 56 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb977 (22 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| az9 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| az10 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa115 | Allele with one deletion | Unknown | Premature Stop | ENU | |
| sa8966 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12381 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45228 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-otpb | Takada et al., 2017 | |
| CRISPR2-otpb | (2) | |
| MO1-otpb | N/A | (2) |
| MO2-otpb | N/A | (2) |
| MO3-otpb | N/A | (5) |
| MO4-otpb | N/A | Ryu et al., 2007 |
| MO5-otpb | N/A | Blechman et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Orthopedia Homeobox |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0S6A5 | InterPro | 315 | ||||||
| UniProtKB:Q6DGH9 | InterPro | 315 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(otpb:GAL4-VP16,myl7:GFP) |
|
| 1 | (20) | |
| Tg1(otpb:EGFP) |
|
| 1 | (6) | |
| Tg2(otpb:EGFP) |
|
| 1 | (10) | |
| Tg2(otpb:GAL4-VP16,myl7:TagRFP) |
|
| 1 | (3) | |
| Tg(otpb:Eco.NsfB-EGFP) |
|
| 1 | (3) | |
| Tg(otpb:EGFP) |
|
| 1 | Ronneberger et al., 2012 | |
| Tg(otpb:GAL4,myl7:EGFP) |
|
| 1 | (4) | |
| Tg(otpb:TagRFP-CAAX) |
|
| 1 | Son et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194B21 | ZFIN Curated Data | |
| Encodes | EST | cb977 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:92914 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191282 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131100 (1) | 1871 nt | ||
| Genomic | GenBank:BX470070 (2) | 228177 nt | ||
| Polypeptide | UniProtKB:B0S6A5 (1) | 315 aa |
- Lu, X., Song, Y., Wang, J., Cai, Y., Peng, S., Lin, J., Lai, B., Sun, J., Liu, T., Chen, G., Xing, L. (2024) Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes. The American journal of pathology. 194(6):1062-1077
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Soto, X., Burton, J., Manning, C.S., Minchington, T., Lea, R., Lee, J., Kursawe, J., Rattray, M., Papalopulu, N. (2022) Sequential and additive expression of miR-9 precursors control timing of neurogenesis. Development (Cambridge, England). 149(19):
- Brown, S.J., Boussaad, I., Jarazo, J., Fitzgerald, J.C., Antony, P., Keatinge, M., Blechman, J., Schwamborn, J.C., Krüger, R., Placzek, M., Bandmann, O. (2021) PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons. Scientific Reports. 11:6617
- Jung, J., Kim, E., Rhee, M. (2021) Kapd Is Essential for Specification of the Dopaminergic Neurogenesis in Zebrafish Embryos. Molecules and cells. 44(4):233-244
- Shi, X., Guan, K., Peng, X., Xu, B., Zhou, X., Wang, S., Xu, S., Zheng, M., Huang, J., Wan, X., Guan, W., Su, K.P., Ye, M., Gao, X., Yin, Z., Li, X. (2021) Ghrelin Modulates Dopaminergic Neuron Formation and Attention Deficit Hyperactivity Disorder-like Behaviors: From Animals to Human Models. Brain, behavior, and immunity. 94:327-337
- Ding, S., Gu, Y., Cai, Y., Cai, M., Yang, T., Bao, S., Shen, W., Ni, X., Chen, G., Xing, L. (2020) Integrative systems and functional analyses reveal a role of dopaminergic signaling in myelin pathogenesis. Journal of translational medicine. 18:109
- Horstick, E.J., Bayleyen, Y., Burgess, H.A. (2020) Molecular and cellular determinants of motor asymmetry in zebrafish. Nature communications. 11:1170
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
- Son, J.H., Stevenson, T.J., Bowles, M.D., Scholl, E.A., Bonkowsky, J.L. (2020) Dopaminergic Co-Regulation of Locomotor Development and Motor Neuron Synaptogenesis is Uncoupled by Hypoxia in Zebrafish. eNeuro. 7(1):
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