Gene
foxo3b
- ID
- ZDB-GENE-990708-6
- Name
- forkhead box O3b
- Symbol
- foxo3b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of defense response to virus; and primitive hemopoiesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Predicted to colocalize with mitochondrial matrix. Is expressed in several structures, including immune system; muscle; nervous system; pericardial region; and posterior lateral mesoderm. Orthologous to human FOXO3 (forkhead box O3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu663 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ihb404 | Allele with one insertion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
ou3012Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
ou3013Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
ou3014 | Allele with one deletion | Unknown | Unknown | CRISPR | |
sa37075 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
1 - 10 of 10
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Forkhead box protein O1, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXO protein, KIX-binding domain | FOXO protein, transactivation domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q9W7F8 | InterPro | 651 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
foxo3b-201
(1)
|
Ensembl | 4,540 nt |
1 - 1 of 1
Interactions and Pathways
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-278N15 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-34A4 | ZFIN Curated Data | |
Encodes | EST | eu663 | Thisse et al., 2005 | |
Encodes | EST | fj65a12 | ZFIN Curated Data | |
Encodes | cDNA | MGC:193582 | ZFIN Curated Data |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131085 (1) | 4547 nt | ||
Genomic | GenBank:BX927123 (1) | 121145 nt | ||
Polypeptide | UniProtKB:Q9W7F8 (1) | 651 aa |
- Deebani, A., Mary, J., Dhinoja, S., Al Qaryoute, A., Fallatah, W., Jagadeeswaran, P. (2025) Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition. Scientific Reports. 15:30583058
- Liu, K., Zhu, Y., Gao, W., Han, X., Zhang, Q., Zhao, Y., Zu, Y. (2024) Resveratrol alleviates heart failure by activating foxo3a to counteract oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 181:117716117716
- Matsumoto, K., Akieda, Y., Haraoka, Y., Hirono, N., Sasaki, H., Ishitani, T. (2024) Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. Nature communications. 15:1066210662
- Ikeda, D., Fujita, S., Toda, K., Yaginuma, Y., Kan-No, N., Watabe, S. (2023) Cold-induced muscle atrophy in zebrafish: Insights from swimming activity and gene expression analysis. Biochemistry and biophysics reports. 36:101570101570
- Stamellou, E., Agrawal, S., Siegerist, F., Buse, M., Kuppe, C., Lange, T., Buhl, E.M., Alam, J., Strieder, T., Boor, P., Ostendorf, T., Gröne, H.J., Floege, J., Smoyer, W.E., Endlich, N., Moeller, M.J. (2023) Inhibition of the glucocorticoid receptor attenuates proteinuric kidney diseases in multiple species. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 39(7):1181-1193
- Xu, H., Mao, X., Nie, Z., Li, Y. (2023) Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Free radical biology & medicine. 203:102-113
- Li, N., Jiang, D., He, L., Yue, Y., Zhang, Q., Wang, S., Zhang, Y., Wei, Y., Zhao, Q. (2022) Both prokaryotes and eukaryotes produce an immune response against plasmids with 5'-GTTTGTT-3'. Cell & Bioscience. 12:87
- Li, R.F., Wang, Y.S., Lu, F.I., Huang, Y.S., Chiu, C.C., Tai, M.H., Wu, C.Y. (2022) Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Biomedicines. 10(6)
- Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668
- Sun, C.C., Yang, D., Chen, Z.L., Xiao, J.L., Xiao, Q., Li, C.L., Zhou, Z.Q., Peng, X.Y., Tang, C.F. (2022) Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction. The FEBS journal. 290(6):1519-1530
1 - 10 of 45
Show