Gene
opn1mw4
- ID
- ZDB-GENE-990604-43
- Name
- opsin 1 (cone pigments), medium-wave-sensitive, 4
- Symbol
- opn1mw4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and detection of light stimulus. Predicted to be located in membrane. Predicted to be active in photoreceptor outer segment and plasma membrane. Is expressed in several structures, including endocrine system; gut; heart; integument; and visual system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20786 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor opsins | G protein-coupled receptor, rhodopsin-like | Opsin | Rhodopsin | Rhodopsin, N-terminal | Visual pigments (opsins) retinal binding site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W6A6 | InterPro | 349 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
opn1mw4-201
(1)
|
Ensembl | 1,379 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(lcr.opn-krt4:EGFP,opn1mw4:RFP) |
| 1 | Tsujimura et al., 2015 | ||
| Tg(lcr.opn-opn1mw1:EGFP,opn1mw4:RFP) |
| 1 | Tsujimura et al., 2015 | ||
| Tg(lcr.opn-opn1mw3:EGFP,opn1mw4:RFP) |
| 1 | Tsujimura et al., 2015 | ||
| Tg(lcr.opn-opn1mw4:EGFP) |
|
| 1 | Tsujimura et al., 2015 | |
| Tg(lcr.opn-opn1mw4:EGFP,opn1mw3:RFP) |
| 1 | Tsujimura et al., 2015 | ||
| Tg(opn1mw4:EGFP) |
|
| 1 | (3) | |
| TgPAC(lcr.opn-opn1mw3:GFP,opn1mw4:RFP) |
| 1 | Tsujimura et al., 2015 | ||
| TgPAC(lcr.opn-opn1mw4:GFP) |
|
| 1 | Tsujimura et al., 2015 |
1 - 8 of 8
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-263A23 | ZFIN Curated Data | |
| Encodes | EST | fk64b02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73141 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131254 (1) | 1398 nt | ||
| Genomic | GenBank:AL732567 (2) | 152840 nt | ||
| Polypeptide | UniProtKB:Q9W6A6 (1) | 349 aa |
No data available
- Hu, H., Qin, Y., Qu, Z., Huang, Y., Ren, X., Liu, M., Liu, F., Gao, P. (2024) The Zpr-3 Antibody Recognizes the 320-354 Region of Rho and Labels Both Rods and Green Cones in Zebrafish. Zebrafish. 21(6):394-400
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Lu, K., Liang, X.F., Tang, S.L., Wu, J., Zhang, L., Wang, Y., Chai, F. (2023) Role of short-wave-sensitive 1 (sws1) in cone development and first feeding in larval zebrafish. Fish physiology and biochemistry. 49(5):801-813
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
- Zhang, J., Jing, M., Li, P., Sun, L., Pi, X., Jiang, N., Zhu, K.K., Li, H., Li, J., Wang, M., Zhang, J., Liu, M., Mu, H., Hu, Y., Cui, X. (2023) Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1869(4):166645
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Liu, F., Qin, Y., Huang, Y., Gao, P., Li, J., Yu, S., Jia, D., Chen, X., Lv, Y., Tu, J., Sun, K., Han, Y., Reilly, J., Shu, X., Lu, Q., Tang, Z., Xu, C., Luo, D., Liu, M. (2022) Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS Genetics. 18:e1009841
- Shi, W.J., Long, X.B., Li, S.Y., Ma, D.D., Liu, F., Zhang, J.G., Lu, Z.J., Ying, G.G. (2022) Dydrogesterone and levonorgestrel at environmentally relevant concentrations have antagonist effects with rhythmic oscillation in brain and eyes of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 248:106177
- Liang, Q., Afriyie, G., Chen, Z., Xu, Z., Dong, Z., Wang, Z., Guo, Y. (2021) Analysis of Opsin Gene Family of Crimson Snapper (Lutjanus erythropterus). Gene. 807:145960
- Deveau, C., Jiao, X., Suzuki, S.C., Krishnakumar, A., Yoshimatsu, T., Hejtmancik, J.F., Nelson, R.F. (2020) Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish). PLoS Genetics. 16:e1008869
1 - 10 of 38
Show