Gene
hoxa10b
- ID
- ZDB-GENE-990415-97
- Name
- homeobox A10b
- Symbol
- hoxa10b Nomenclature History
- Previous Names
-
- Hoxa-10
- hoxa10
- z-140
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including CNS interneuron; chondroblast; fin; myoblast; and pectoral fin bud. Orthologous to human HOXA10 (homeobox A10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ihb432 | Allele with one deletion | Unknown | Unknown | CRISPR | |
ihb433 | Allele with one deletion | Unknown | Unknown | CRISPR | |
sa42704 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sud159 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
sud165b | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-hoxa10b | Zebrafish Nomenclature Committee | |
CRISPR2-hoxa10b | Adachi et al., 2024 | |
MO1-hoxa10b | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein Hox-A10/abdominal-B-like | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B4B4 | InterPro | 346 | |||||
UniProtKB:Q8AWY2 | InterPro | 330 | |||||
UniProtKB:B3DGC1 | InterPro | 330 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hoxa10b-201
(1)
|
Ensembl | 1,649 nt | ||
mRNA | ottdart00000001853 (1) | Havana | 1,232 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hoxa10b-E1B:EGFP) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-45E15 | ZFIN Curated Data | |
Contained in | PAC | BUSM1-31B14 | ZFIN Curated Data | |
Encodes | cDNA | MGC:193973 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131155 (1) | 1760 nt | ||
Genomic | GenBank:CR392024 (2) | 183486 nt | ||
Polypeptide | UniProtKB:A0A8M2B4B4 (1) | 346 aa |
- Adachi, U., Koita, R., Seto, A., Maeno, A., Ishizu, A., Oikawa, S., Tani, T., Ishizaka, M., Yamada, K., Satoh, K., Nakazawa, H., Furudate, H., Kawakami, K., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Teleost Hox code defines regional identities competent for the formation of dorsal and anal fins. Proceedings of the National Academy of Sciences of the United States of America. 121:e2403809121e2403809121
- Ishizaka, M., Maeno, A., Nakazawa, H., Fujii, R., Oikawa, S., Tani, T., Kanno, H., Koita, R., Kawamura, A. (2024) The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development. Scientific Reports. 14:2360223602
- Cotellessa, L., Marelli, F., Duminuco, P., Adamo, M., Papadakis, G.E., Bartoloni, L., Sato, N., Lang-Muritano, M., Troendle, A., Dhillo, W.S., Morelli, A., Guarnieri, G., Pitteloud, N., Persani, L., Bonomi, M., Giacobini, P., Vezzoli, V. (2023) Defective Jagged1 signaling impacts GnRH development and contributes to congenital hypogonadotropic hypogonadism. JCI insight. 8(5):
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Smeeton, J., Natarajan, N., Naveen Kumar, A., Miyashita, T., Baddam, P., Fabian, P., Graf, D., Crump, J.G. (2021) Zebrafish Model for Spondylo-Megaepiphyseal-Metaphyseal Dysplasia Reveals Post-Embryonic Roles of Nkx3.2 in the Skeleton. Development (Cambridge, England). 148(2):
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Messina, A., Pulli, K., Santini, S., Acierno, J., Känsäkoski, J., Cassatella, D., Xu, C., Casoni, F., Malone, S.A., Ternier, G., Conte, D., Sidis, Y., Tommiska, J., Vaaralahti, K., Dwyer, A., Gothilf, Y., Merlo, G.R., Santoni, F., Niederländer, N.J., Giacobini, P., Raivio, T., Pitteloud, N. (2019) Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism. American journal of human genetics. 106(1):58-70
- Zuccarini, G., D'Atri, I., Cottone, E., Mackie, K., Shainer, I., Gothilf, Y., Provero, P., Bovolin, P., Merlo, G.R. (2019) Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos. International Journal of Molecular Sciences. 21(1):
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
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