Gene
hsp90aa1.1
- ID
- ZDB-GENE-990415-94
- Name
- heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
- Symbol
- hsp90aa1.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Acts upstream of or within leukocyte migration; myofibril assembly; and response to metal ion. Located in Z disc. Is expressed in several structures, including immature eye; musculature system; paraxial mesoderm; pericardial region; and skeletal muscle myoblast. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 52 figures from 28 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la028290Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa1396 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa14009 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa16631 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa30722 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
tm201 | Allele with one point mutation | Exon 10 | Premature Stop | ENU | |
tu44c | Allele with one point mutation | Exon 9 | Premature Stop | ENU | |
u45 | Allele with one point mutation | Exon 3 | Missense | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-hsp90aa1.1 | Paone et al., 2018 | |
CRISPR2-hsp90aa1.1 | Cai et al., 2018 | |
CRISPR3-hsp90aa1.1 | Cai et al., 2018 | |
CRISPR4-hsp90aa1.1 | Cai et al., 2018 | |
MO1-hsp90aa1.1 | N/A | (2) |
MO1-hsp90aa1.1,hsp90aa1.2 | N/A | Pfeiffer et al., 2018 |
MO2-hsp90aa1.1 | N/A | (3) |
MO3-hsp90aa1.1 | N/A | (2) |
MO4-hsp90aa1.1 | N/A | (9) |
MO5-hsp90aa1.1 | N/A | Du et al., 2008 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019805 | Heat shock protein Hsp90, conserved site |
Domain | IPR003594 | Histidine kinase/HSP90-like ATPase domain |
Domain | IPR020575 | Heat shock protein Hsp90, N-terminal |
Family | IPR001404 | Heat shock protein Hsp90 family |
Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Heat shock protein Hsp90, conserved site | Heat shock protein Hsp90 family | Heat shock protein Hsp90, N-terminal | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | HSP90, C-terminal domain | Ribosomal protein uS5 domain 2-type superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q90474 | InterPro | 725 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hsp90aa1.1-201
(1)
|
Ensembl | 2,543 nt | ||
mRNA |
hsp90aa1.1-203
(1)
|
Ensembl | 2,375 nt | ||
ncRNA |
hsp90aa1.1-002
(1)
|
Ensembl | 283 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-241L7 | ZFIN Curated Data | |
Encodes | EST | fb17b01 | ZFIN Curated Data | |
Encodes | cDNA | MGC:86652 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131328 (1) | 2474 nt | ||
Genomic | GenBank:CR381646 (2) | 183151 nt | ||
Polypeptide | UniProtKB:Q90474 (1) | 725 aa |
- Rajeswari, J.J., Gilbert, G.N.Y., Khalid, E., Vijayan, M.M. (2025) Brain monoamine changes modulate the corticotropin-releasing hormone receptor 1-mediated behavioural response to acute thermal stress in zebrafish larvae. Molecular and Cellular Endocrinology. :112494112494
- Xiao, H., Li, M., Zhong, Y., Patel, A., Xu, R., Zhang, C., Athey, T.W., Fang, S., Xu, T., Du, S. (2025) Hsf1 is essential for proteotoxic stress response in smyd1b-deficient embryos and fish survival under heat shock. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 39:e70283e70283
- Xu, R., Li, S., Chien, C.J., Zhong, Y., Xiao, H., Fang, S., Du, S. (2024) Expression of Smyd1b_tv1 by Alternative Splicing in Cardiac Muscle is Critical for Sarcomere Organization in Cardiomyocytes and Heart Function. Molecular and cellular biology. 44(12):543-561
- Chen, D.D., Liu, B., Wang, Y., Jiang, M., Shang, G., Xue, M., Jia, X., Lang, Y., Zhou, G., Zhang, F., Peng, X., Hu, Y. (2023) The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22832e22832
- Fu, J.L., Zheng, S.Y., Wang, Y., Hu, X.B., Xiao, Y., Wang, J.M., Zhang, L., Wang, L., Nie, Q., Hou, M., Bai, Y.Y., Gan, Y.W., Liang, X.M., Xie, L.L., Li, D.W. (2023) HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221522120e2221522120
- He, T., Lykov, N., Luo, X., Wang, H., Du, Z., Chen, Z., Chen, S., Zhu, L., Zhao, Y., Tzeng, C. (2023) Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. International Journal of Molecular Sciences. 24(3):
- Lim, M.Y., Bernier, N.J. (2023) Intergenerational plasticity to cycling high temperature and hypoxia affects offspring stress responsiveness and tolerance in zebrafish. The Journal of experimental biology. 226(16):
- Lim, M.Y., Bernier, N.J. (2022) Zebrafish parental progeny investment in response to cycling thermal stress and hypoxia: deposition of heat shock proteins but not cortisol. The Journal of experimental biology. 225(21):
- Livne, H., Avital, T., Ruppo, S., Harazi, A., Mitrani-Rosenbaum, S., Daya, A. (2022) Generation and characterization of a novel gne Knockout Model in Zebrafish. Frontiers in cell and developmental biology. 10:976111
- Morgan, R., Andreassen, A.H., Åsheim, E.R., Finnøen, M.H., Dresler, G., Brembu, T., Loh, A., Miest, J.J., Jutfelt, F. (2022) Reduced physiological plasticity in a fish adapted to stable temperatures. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201919119
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