Gene
her5
- ID
- ZDB-GENE-990415-90
- Name
- hairy-related 5
- Symbol
- her5 Nomenclature History
- Previous Names
-
- zgc:136537
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity and protein homodimerization activity. Acts upstream of or within several processes, including midbrain-hindbrain boundary development; negative regulation of neurogenesis; and positive regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be active in nucleus. Is expressed in several structures, including EVL; brain; endoderm; neural plate; and presumptive structure. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 4. Orthologous to human HES7 (hes family bHLH transcription factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 49 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu359 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Shin et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12026 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-her5 | Miao et al., 2022 | |
| CRISPR2-her5 | Miao et al., 2022 | |
| CRISPR3-her5 | Miao et al., 2022 | |
| CRISPR4-her5 | Miao et al., 2022 | |
| MO1-her5 | N/A | (5) |
| MO2-her5 | N/A | Coolen et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 4 | Alliance | Spondylocostal dysostosis 4, autosomal recessive | 613686 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003650 | Orange domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR032644 | Transcription factor HES-7, basic helix-loop-helix-orange domain |
| Family | IPR050370 | Hairy and Enhancer of Split/HEY-related |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Hairy and Enhancer of Split/HEY-related | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Orange domain | Transcription factor HES-7, basic helix-loop-helix-orange domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90467 | InterPro | 205 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.7her5:EGFP) |
|
| 1 | (12) | |
| Tg(-1.7her5:EGFP) |
|
| 1 | (5) | |
| Tg(-3.4her5:EGFP) |
|
| 1 | (18) | |
| TgBAC(her5:ERT2-Cre-ERT2) |
|
| 1 | (3) | |
| TgBAC(her5:NLS-mCherry,myl7:EGFP) |
|
| 1 | (2) | |
| Tg(her5:mCherry-CAAX) |
|
| 1 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-271E23 | ZFIN Curated Data | |
| Contained in | BAC | CH211-153K16 | Gajewski et al., 2006 | |
| Encodes | EST | eu359 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:136537 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158599 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131077 (1) | 1179 nt | ||
| Genomic | GenBank:BX323810 (1) | 166625 nt | ||
| Polypeptide | UniProtKB:Q90467 (1) | 205 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | HES7 | 17 | Amino acid sequence comparison (1) |
- Chen, Y.C., Hsieh, F.Y., Chang, C.W., Sun, M.Q., Cheng, Y.C. (2024) Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment. International Journal of Molecular Sciences. 25(17):
- Etchegaray, E., Baas, D., Naville, M., Haftek-Terreau, Z., Volff, J.N. (2022) The neurodevelopmental gene MSANTD2 belongs to a gene family formed by recurrent molecular domestication of Harbinger transposons at the base of vertebrates. Molecular Biology and Evolution. 39(8):
- Miao, L., Tang, Y., Bonneau, A.R., Chan, S.H., Kojima, M.L., Pownall, M.E., Vejnar, C.E., Gao, F., Krishnaswamy, S., Hendry, C.E., Giraldez, A.J. (2022) The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation. Molecular Cell. 82(5):986-1002.e9
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Ozalp, O., Cark, O., Azbazdar, Y., Haykir, B., Cucun, G., Kucukaylak, I., Alkan-Yesilyurt, G., Sezgin, E., Ozhan, G. (2021) Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis. Biomolecules. 11(1):
- Green, D.G., Whitener, A.E., Mohanty, S., Mistretta, B., Gunaratne, P., Yeh, A.T., Lekven, A.C. (2020) Wnt signaling regulates neural plate patterning in distinct temporal phases with dynamic transcriptional outputs. Developmental Biology. 462(2):152-164
- Guo, Y., Cheng, B.Y.L., Wang, D., Ma, A.C.H., He, B.L., Man, T.K., Cheung, M.P.L., Shi, X., Ng, N.K.L., Leung, A.Y.H. (2020) Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium. Stem Cell Reports. 14(4):575-589
- Azbazdar, Y., Ozalp, O., Sezgin, E., Veerapathiran, S., Duncan, A.L., Sansom, M.S.P., Eggeling, C., Wohland, T., Karaca, E., Ozhan, G. (2019) More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains. Frontiers in cell and developmental biology. 7:281
- Bloch, S., Thomas, M., Colin, I., Galant, S., Machado, E., Affaticati, P., Jenett, A., Yamamoto, K. (2019) Mesencephalic origin of the inferior lobe in zebrafish. BMC Biology. 17:22
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