Gene
ran
- ID
- ZDB-GENE-990415-88
- Name
- RAN, member RAS oncogene family
- Symbol
- ran Nomenclature History
- Previous Names
-
- fc16b04
- wu:fc16b04 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity; GTPase activity; and magnesium ion binding activity. Acts upstream of or within neural retina development. Predicted to be located in cytosol and nuclear envelope. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; digestive system; eye; pronephros; and splanchnocranium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65833 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| tju4 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ran | Hu et al., 2019 | |
| MO1-ran | N/A | Lin et al., 2015 |
| MO2-ran | N/A | Lin et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Ran GTPase | Small GTPase | Small GTP-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q6GTE7 | InterPro | 215 | ||||
| UniProtKB:P79735 | InterPro | 215 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-83D4 | ZFIN Curated Data | |
| Contains | SNP | rs3729491 | Stickney et al., 2002 | |
| Contains | SNP | rs3729492 | Stickney et al., 2002 | |
| Contains | SNP | rs3729493 | Stickney et al., 2002 | |
| Encodes | EST | fc16b04 | ZFIN Curated Data | |
| Encodes | EST | fq36g07 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:56301 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65833 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131309 (1) | 1418 nt | ||
| Genomic | GenBank:CT955967 (1) | 131798 nt | ||
| Polypeptide | UniProtKB:P79735 (1) | 215 aa |
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Hunter, M.V., Moncada, R., Weiss, J.M., Yanai, I., White, R.M. (2021) Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nature communications. 12:6278
- Can, H., Chanumolu, S.K., Gonzalez-Muñoz, E., Prukudom, S., Otu, H.H., Cibelli, J.B. (2020) Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. BMC Genomics. 21:471
- Ayobahan, S.U., Eilebrecht, E., Kotthoff, M., Baumann, L., Eilebrecht, S., Teigeler, M., Hollert, H., Kalkhof, S., Schäfers, C. (2019) A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Scientific Reports. 9:6599
- Hu, R., Huang, W., Liu, J., Jin, M., Wu, Y., Li, J., Wang, J., Yu, Z., Wang, H., Cao, Y. (2019) Mutagenesis of putative ciliary genes with the CRISPR/Cas9 system in zebrafish identifies genes required for retinal development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(4):5248-5256
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lin, C.Y., Huang, H.Y., Lu, P.N., Lin, C.W., Lu, K.M., Tsai, H.J. (2015) Ras-Related Nuclear Protein is required for late developmental stages of retinal cells in zebrafish eyes. The International journal of developmental biology. 59:435-442
- Singh, S.K., Aravamudhan, S., Armant, O., Krüger, M., Grabher, C. (2014) Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation. Fish & shellfish immunology. 40(1):217-24
- Carlson, P., Smalley, D.M., and Van Beneden, R.J. (2013) Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Toxicological sciences : an official journal of the Society of Toxicology. 134(1):83-91
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