Gene

gata3

ID
ZDB-GENE-990415-82
Name
GATA binding protein 3
Symbol
gata3 Nomenclature History
Previous Names
  • gta3 (1)
  • cb550 (1)
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; fin regeneration; and positive regulation of neuron migration. Acts upstream of or within cardiac muscle tissue regeneration; embryonic organ morphogenesis; and ventral spinal cord interneuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; ectoderm; nervous system; neural tube; and pleuroperitoneal region. Used to study hypoparathyroidism-retardation-dysmorphism syndrome. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Orthologous to human GATA3 (GATA binding protein 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
94 figures from 60 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
au42Allele with one delinsExon 2UnknownCRISPR
b1075Allele with one point mutationExon 4Missensenot specified
sa0234Allele with one delinsUnknownPremature Stopzinc finger nuclease
sa20285Allele with one point mutationUnknownPremature StopENU
sa40301Allele with one point mutationUnknownPremature StopENU
sa40302Allele with one point mutationUnknownSplice SiteENU
sa40303Allele with one point mutationUnknownPremature StopENU
stl600TgTransgenic insertionUnknownUnknownDNA and CRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With gata3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypoparathyroidism-deafness-renal disease syndrome Alliance Hypoparathyroidism, sensorineural deafness, and renal dysplasia 146255
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Associated With gata3 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000679 Zinc finger, GATA-type
Family IPR016374 Transcription factor, GATA-2/3
Family IPR039355 Transcription factor GATA
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
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Domain Details Per Protein
Protein Additional Resources Length Transcription factor GATA Transcription factor, GATA-2/3 Zinc finger, GATA-type Zinc finger, NHR/GATA-type
UniProtKB:A0A8M2BC31 InterPro 384
UniProtKB:Q91428 InterPro 438
UniProtKB:A0A8M2BC50 InterPro 403
UniProtKB:B3DGG5 InterPro 438
UniProtKB:A0A8M9Q5R9 InterPro 382
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 4
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gata3-201 (1) Ensembl 2,576 nt
ncRNA gata3-002 (1) Ensembl 685 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(gata3:AmCyan)
  • gata3
  • Danio rerio
1 (2)
TgBAC(gata3:GAL4)
  • gata3
  • Danio rerio
1 (2)
TgBAC(gata3:LOXP-DsRed-LOXP-GFP)
  • gata3
  • Danio rerio
1 (4)
Tg(HSE-CMV:gata3,EGFP)
  • Danio rerio
1Yao et al., 2014
Tg(hsp70l:gata3)
  • gata3
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-268B12ZFIN Curated Data
EncodesESTcb550Thisse et al., 2001
EncodescDNAMGC:194063ZFIN Curated Data
EncodescDNAMGC:194082ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGATA310
Amino acid sequence comparison (4)
Conserved genome location (synteny) (2)
Phylogenetic tree (1)
MouseGata32
Conserved genome location (synteny) (1)
Amino acid sequence comparison (4)
Phylogenetic tree (1)
Citations
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