Gene
noto
- ID
- ZDB-GENE-990415-75
- Name
- notochord homeobox
- Symbol
- noto Nomenclature History
- Previous Names
-
- Znot
- flh
- floating head
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including embryonic morphogenesis; endocrine system development; and regionalization. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; forebrain; germ ring; mesoderm; and tail bud. Orthologous to human NOTO (notochord homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 122 figures from 94 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 53 figures from 32 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| is14Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| la620 | unknown | Unknown | Unknown | ENU | |
| la018405Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m614 | unknown | Unknown | Unknown | ENU | |
| n1 | Allele with one deletion | Unknown | Frameshift | spontaneous | |
| noto_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| sa42164 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tk241 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tm229 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EMX/VAX/Noto Homeobox Transcription Factors | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain |
|---|---|---|---|---|---|---|
| UniProtKB:Q90461 | InterPro | 241 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.6flh:GAP-EGFP) |
|
| 1 | (15) | |
| TgBAC(flh:flh-Kaede) |
|
|
| 1 | (7) |
| Tg(flh:EGFP) |
|
| 2 | (13) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-159C24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193971 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131055 (1) | 953 nt | ||
| Genomic | GenBank:BX571943 (2) | 102576 nt | ||
| Polypeptide | UniProtKB:Q90461 (1) | 241 aa |
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Moreno-Sánchez, I., Hernández-Huertas, L., Nahón-Cano, D., Martínez-García, P.M., Treichel, A.J., Gómez-Marin, C., Tomás-Gallardo, L., da Silva Pescador, G., Kushawah, G., Egidy, R., Perera, A., Díaz-Moscoso, A., Cano-Ruiz, A., Walker, J.A., Muñoz, M.J., Holden, K., Galcerán, J., Nieto, M.Á., Bazzini, A.A., Moreno-Mateos, M.A. (2025) Enhanced RNA-targeting CRISPR-Cas technology in zebrafish. Nature communications. 16:25912591
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Wang, Y., Sun, X., Xiong, B., Duan, M., Sun, Y. (2024) Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish. International Journal of Molecular Sciences. 25(17):
- Kamimoto, K., Stringa, B., Hoffmann, C.M., Jindal, K., Solnica-Krezel, L., Morris, S.A. (2023) Dissecting cell identity via network inference and in silico gene perturbation. Nature. 614(7949):742-751
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Chang, N.C., Rovira, Q., Wells, J.N., Feschotte, C., Vaquerizas, J.M. (2022) Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression. Genome research. 32(7):1408-1423
- Gao, M., Veil, M., Rosenblatt, M., Riesle, A.J., Gebhard, A., Hass, H., Buryanova, L., Yampolsky, L.Y., Grüning, B., Ulianov, S.V., Timmer, J., Onichtchouk, D. (2022) Pluripotency factors determine gene expression repertoire at zygotic genome activation. Nature communications. 13:788
- Ikeda, T., Inamori, K., Kawanishi, T., Takeda, H. (2022) Reemployment of Kupffer's vesicle cells into axial and paraxial mesoderm via transdifferentiation. Development, growth & differentiation. 64(3):163-177
- Paulissen, E., Palmisano, N.J., Waxman, J., Martin, B.L. (2022) Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLIFE. 11:
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