Gene
etv4
- ID
- ZDB-GENE-990415-71
- Name
- ETS variant transcription factor 4
- Symbol
- etv4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within limb morphogenesis and pronephric nephron tubule epithelial cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including fin; head; mesoderm; nervous system; and neural keel. Orthologous to human ETV4 (ETS variant transcription factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 114 figures from 82 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76984 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Marra et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3536 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la010075Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la011544Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018185Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018186Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa45463 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000418 | Ets domain |
| Domain | IPR006715 | PEA3-type ETS-domain transcription factor, N-terminal |
| Family | IPR046328 | ETS family |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ets domain | ETS family | PEA3-type ETS-domain transcription factor, N-terminal | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AY95 | InterPro | 495 | |||||
| UniProtKB:A0A8N1TV56 | InterPro | 494 | |||||
| UniProtKB:Q9PUQ1 | InterPro | 494 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-69O7 | ZFIN Curated Data | |
| Encodes | EST | fc19f01 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76984 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131425 (1) | 1848 nt | ||
| Genomic | GenBank:AL833789 (1) | 175664 nt | ||
| Polypeptide | UniProtKB:A0A8M3AY95 (1) | 495 aa |
- Olson, H.M., Maxfield, A., Calistri, N.L., Heiser, L.M., Qian, W., Knaut, H., Nechiporuk, A.V. (2024) RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration. Development (Cambridge, England). 151(1):
- Tuttle, A.M., Miller, L.N., Royer, L.J., Wen, H., Kelly, J.J., Calistri, N.L., Heiser, L.M., Nechiporuk, A.V. (2024) Single-cell analysis of Rohon-Beard neurons implicates Fgf signaling in axon maintenance and cell survival. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(16):
- Harish, R.K., Gupta, M., Zöller, D., Hartmann, H., Gheisari, A., Machate, A., Hans, S., Brand, M. (2023) Real-time monitoring of endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation. Development (Cambridge, England). 150(19):
- Hernández-Bejarano, M., Gestri, G., Monfries, C., Tucker, L., Dragomir, E.I., Bianco, I.H., Bovolenta, P., Wilson, S.W., Cavodeassi, F. (2022) Foxd1-dependent induction of a temporal retinal character is required for visual function. Development (Cambridge, England). 149(24):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Rayrikar, A.Y., Wagh, G.A., Santra, M., Patra, C. (2022) Ccn2a-FGFR1-SHH signaling is necessary for intervertebral disc homeostasis and regeneration in adult zebrafish. Development (Cambridge, England). 150(1):
- Tang, D., Zheng, S., Zheng, Z., Liu, C., Zhang, J., Yan, R., Wu, C., Zuo, N., Wu, L., Xu, H., Liu, S., He, Y. (2022) Dnmt1 is required for the development of auditory organs via cell cycle arrest and Fgf signalling. Cell Proliferation. 55(5):e13225
- Chu, S., Kwon, B.R., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Effects of 2-ethylhexyl-4-methoxycinnamate (EHMC) on thyroid hormones and genes associated with thyroid, neurotoxic, and nephrotoxic responses in adult and larval zebrafish (Danio rerio). Chemosphere. 263:128176
- Nakajima, W., Nakanishi, S., Hosoya, R., Uemoto, T., Ohgo, S., Wada, N. (2021) Regenerative Polarity of the Fin Ray in Zebrafish Caudal Fin and Related Tissue Formation on the Cut Surface. Journal of developmental biology. 9(4):
- Song, Y., Hyeon, C. (2021) Cost-precision trade-off relation determines the optimal morphogen gradient for accurate biological pattern formation. eLIFE. 10:
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