Gene

ek1

ID
ZDB-GENE-990415-58
Name
eph-like kinase 1
Symbol
ek1 Nomenclature History
Previous Names
  • epha4d (1)
  • etID309879.24 (1)
  • rtk7
  • zek1
  • zgc:100780
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable GPI-linked ephrin receptor activity. Predicted to be involved in several processes, including axonal fasciculation; ephrin receptor signaling pathway; and regulation of cytoskeleton organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in early endosome. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in central nervous system and neural tube. Orthologous to human EPHA1 (EPH receptor A1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la022963TgTransgenic insertionUnknownUnknownDNA
la028629TgTransgenic insertionUnknownUnknownDNA
la028630TgTransgenic insertionUnknownUnknownDNA
sa8415Allele with one point mutationUnknownPremature StopENU
sa8869Allele with one point mutationUnknownPremature StopENU
sa24519Allele with one point mutationUnknownPremature StopENU
sa37911Allele with one point mutationUnknownPremature StopENU
sa37912Allele with one point mutationUnknownPremature StopENU
sa39457Allele with one point mutationUnknownPremature StopENU
sa44161Allele with one point mutationUnknownPremature StopENU
1 - 10 of 10
Show
Sequence Targeting Reagents
No data available
Human Disease
Associated With ek1 Human Ortholog
No data available
Associated With ek1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001090 Ephrin receptor ligand binding domain
1 - 5 of 18 Show all
Domain Details Per Protein
Protein Additional Resources Length Ephrin receptor ligand binding domain Ephrin receptor, transmembrane domain Ephrin receptor type-A /type-B Ephrin receptor tyrosine kinases Fibronectin type III Fibronectin type III superfamily Galactose-binding-like domain superfamily Growth factor receptor cysteine-rich domain superfamily Immunoglobulin-like fold Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class V, conserved site
UniProtKB:O13146 InterPro 981
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 24
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ek1-201 (1) Ensembl 4,537 nt
mRNA ek1-202 (1) Ensembl 1,968 nt
ncRNA ek1-003 (1) Ensembl 475 nt
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-260D11ZFIN Curated Data
Contained inBACDKEY-39F23ZFIN Curated Data
EncodesESTeu792Thisse et al., 2005
EncodescDNAMGC:100780ZFIN Curated Data
EncodescDNAMGC:193628ZFIN Curated Data
1 - 5 of 5
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
No data available
Citations
1 - 10 of 12
Show