Gene
ek1
- ID
- ZDB-GENE-990415-58
- Name
- eph-like kinase 1
- Symbol
- ek1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable GPI-linked ephrin receptor activity. Predicted to be involved in several processes, including axonal fasciculation; ephrin receptor signaling pathway; and regulation of cytoskeleton organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in early endosome. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in central nervous system and neural tube. Orthologous to human EPHA1 (EPH receptor A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu792 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la022963Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028629Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028630Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa8415 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa8869 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa24519 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa37911 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa37912 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa39457 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa44161 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 10 of 10
Show
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008266 | Tyrosine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Conserved_site | IPR001426 | Tyrosine-protein kinase, receptor class V, conserved site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001090 | Ephrin receptor ligand binding domain |
1 - 5 of 18 Show all
Domain Details Per Protein
Protein | Additional Resources | Length | Ephrin receptor ligand binding domain | Ephrin receptor, transmembrane domain | Ephrin receptor type-A /type-B | Ephrin receptor tyrosine kinases | Fibronectin type III | Fibronectin type III superfamily | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class V, conserved site |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:O13146 | InterPro | 981 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-260D11 | ZFIN Curated Data | |
Contained in | BAC | DKEY-39F23 | ZFIN Curated Data | |
Encodes | EST | eu792 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:100780 | ZFIN Curated Data | |
Encodes | cDNA | MGC:193628 | ZFIN Curated Data |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131095 (1) | 4577 nt | ||
Genomic | GenBank:CR352262 (1) | 222164 nt | ||
Polypeptide | UniProtKB:O13146 (1) | 981 aa |
No data available
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gao, X., Metzger, U., Panza, P., Mahalwar, P., Alsheimer, S., Geiger, H., Maischein, H.M., Levesque, M.P., Templin, M., Söllner, C. (2015) A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. Cell Reports. 12(4):694-708
- Challa, A.K., and Chatti, K. (2013) Conservation and Early Expression of Zebrafish Tyrosine Kinases Support the Utility of Zebrafish as a Model for Tyrosine Kinase Biology. Zebrafish. 10(3):264-74
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Scholpp, S. and Brand, M. (2003) Integrity of the midbrain region is required to maintain the diencephalic-mesencephalic boundary in zebrafish no isthmus/pax2.1 mutants. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):313-322
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Bovenkamp, D.E. and Greer, P.A. (2001) Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature. DNA and cell biology. 20(4):203-213
- Holder, N., and Klein, R. (1999) Eph receptors and ephrins: effectors of morphogenesis. Development (Cambridge, England). 126(10):2033-2044
1 - 10 of 12
Show