Gene
emx3
- ID
- ZDB-GENE-990415-53
- Name
- empty spiracles homeobox 3
- Symbol
- emx3 Nomenclature History
- Previous Names
-
- emx1 (1)
- zgc:110517
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within central nervous system projection neuron axonogenesis; early neuron differentiation in forebrain; and telencephalon development. Predicted to be active in nucleus. Is expressed in several structures, including anterior neural rod; forebrain; forebrain neural plate; neural keel; and periderm.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 85 figures from 56 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu682 (20 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-emx3 | N/A | (2) |
| MO2-emx3 | N/A | Viktorin et al., 2009 |
| MO3-emx3 | N/A | Viktorin et al., 2009 |
| MO4-emx3 | N/A | Viktorin et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EMX/VAX/Noto Homeobox Transcription Factors | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90263 | InterPro | 233 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(emx3:emx3-MYC-GFP) |
|
|
| 1 | (3) |
| Tg(emx3:YFP) |
|
| 1 | (11) | |
| Tg(emx3:YFPm) |
|
| 1 | (4) | |
| Tg(hsp70l:emx3-MYC-GFP) |
|
| 1 | (6) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-263G20 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-110E4 | ZFIN Curated Data | |
| Encodes | EST | eu682 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:110517 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193008 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131279 (1) | 1144 nt | ||
| Genomic | GenBank:BX323077 (2) | 195732 nt | ||
| Polypeptide | UniProtKB:Q90263 (1) | 233 aa |
No data available
- Chowdhury, G., Umeda, K., Ohyanagi, T., Nasu, K., Yamasu, K. (2024) Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development. Development, growth & differentiation. 66(2):145-160
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Bulk, J., Kyrychenko, V., Rensinghoff, P.M., Ghaderi Ardekani, Z., Heermann, S. (2023) Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish. International Journal of Molecular Sciences. 24(9):
- Hernández-Bejarano, M., Gestri, G., Monfries, C., Tucker, L., Dragomir, E.I., Bianco, I.H., Bovolenta, P., Wilson, S.W., Cavodeassi, F. (2022) Foxd1-dependent induction of a temporal retinal character is required for visual function. Development (Cambridge, England). 149(24):
- Messina, A., Potrich, D., Schiona, I., Sovrano, V.A., Fraser, S.E., Brennan, C.H., Vallortigara, G. (2021) Neurons in the Dorso-Central Division of Zebrafish Pallium Respond to Change in Visual Numerosity. Cerebral cortex (New York, N.Y. : 1991). 32(2):418-428
- Werner, J.M., Negesse, M.Y., Brooks, D.L., Caldwell, A.R., Johnson, J.M., Brewster, R.M. (2021) Hallmarks of primary neurulation are conserved in the zebrafish forebrain. Communications biology. 4:147
- Jung, J., Choi, I., Ro, H., Huh, T.L., Choe, J., Rhee, M. (2020) march5 Governs the Convergence and Extension Movement for Organization of the Telencephalon and Diencephalon in Zebrafish Embryos. Molecules and cells. 43(1):76-85
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
- Young, R.M., Ewan, K.B., Ferrer, V.P., Allende, M.L., Godovac-Zimmermann, J., Dale, T.C., Wilson, S.W. (2019) Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation. eLIFE. 8:
- Young, R.M., Hawkins, T.A., Cavodeassi, F., Stickney, H.L., Schwarz, Q., Lawrence, L.M., Wierzbicki, C., Cheng, B.Y., Luo, J., Ambrosio, E.M., Klosner, A., Sealy, I.M., Rowell, J., Trivedi, C.A., Bianco, I.H., Allende, M.L., Busch-Nentwich, E.M., Gestri, G., Wilson, S.W. (2019) Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification. eLIFE. 8:
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