Gene
wnt8b
- ID
- ZDB-GENE-990415-279
- Name
- wingless-type MMTV integration site family, member 8b
- Symbol
- wnt8b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including nervous system development; neural plate regionalization; and otic placode formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including anterior neural rod; brain; midbrain hindbrain boundary neural keel; midbrain hindbrain boundary neural rod; and neural plate. Human ortholog(s) of this gene implicated in Hirschsprung's disease. Orthologous to human WNT8B (Wnt family member 8B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 29 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu387 (18 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-wnt8b | LaCoursiere et al., 2024 | |
CRISPR2-wnt8b | LaCoursiere et al., 2024 | |
MO1-wnt8b | N/A | (4) |
MO2-wnt8b | N/A | (7) |
MO3-wnt8b | N/A | Shima et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Wnt | Wnt-8 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
---|---|---|---|---|---|---|
UniProtKB:P51029 | InterPro | 358 |
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Interactions and Pathways
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEYP-115D2 | ZFIN Curated Data | |
Contained in | BAC | RP71-68N3 | ZFIN Curated Data | |
Encodes | EST | eu387 | Thisse et al., 2005 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_130959 (1) | 1264 nt | ||
Genomic | GenBank:AL929344 (2) | 190898 nt | ||
Polypeptide | UniProtKB:P51029 (1) | 358 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
- Ha, T.T., Burgess, R., Newman, M., Moey, C., Mandelstam, S.A., Gardner, A.E., Ivancevic, A.M., Pham, D., Kumar, R., Smith, N., Patel, C., Malone, S., Ryan, M.M., Calvert, S., van Eyk, C.L., Lardelli, M., Berkovic, S.F., Leventer, R.J., Richards, L.J., Scheffer, I.E., Gecz, J., Corbett, M.A. (2023) Aicardi Syndrome Is a Genetically Heterogeneous Disorder. Genes. 14(8):
- Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
- Naraine, R., Iegorova, V., Abaffy, P., Franek, R., Soukup, V., Psenicka, M., Sindelka, R. (2022) Evolutionary conservation of maternal RNA localization in fishes and amphibians revealed by TOMO-Seq. Developmental Biology. 489:146-160
- Westphal, M., Panza, P., Kastenhuber, E., Wehrle, J., Driever, W. (2022) Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish. Scientific Reports. 12:1030
- Jung, J., Kim, E., Rhee, M. (2021) Kapd Is Essential for Specification of the Dopaminergic Neurogenesis in Zebrafish Embryos. Molecules and cells. 44(4):233-244
- Lin, Z., Luo, M., Zhou, B., Liu, Y., Sun, H. (2021) CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish. Immunology Letters. 234:47-53
- Cang, Z., Nie, Q. (2020) Inferring spatial and signaling relationships between cells from single cell transcriptomic data. Nature communications. 11:2084
- Zhang, Q., Zhang, C., Zhang, C., Peng, G. (2020) Wnt Signaling Regulates Ipsilateral Pathfinding in the Zebrafish Forebrain through slit3. Neuroscience. 449:9-20
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