Gene
tpma
- ID
- ZDB-GENE-990415-269
- Name
- alpha-tropomyosin
- Symbol
- tpma Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Acts upstream of or within myeloid cell development. Predicted to be located in actin cytoskeleton. Predicted to be active in actin filament. Is expressed in adaxial cell; male organism; musculature system; pericardial region; and somite. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Orthologous to human TPM1 (tropomyosin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77897 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gieger et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000533 | Tropomyosin |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Tropomyosin |
|---|---|---|---|
| UniProtKB:P13104 | InterPro | 284 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-4.0tpma:EGFP) |
|
| 1 | (3) | |
| Tg(tpma:KALTA4,4xUAS:EGFP) |
|
| 1 | Pang et al., 2015 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-148P15 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-132M23 | ||
| Encodes | EST | fb37a09 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77897 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131105 (1) | 1406 nt | ||
| Genomic | GenBank:AL845510 (1) | 101241 nt | ||
| Polypeptide | UniProtKB:P13104 (1) | 284 aa |
No data available
- Bradshaw, M., Squire, J.M., Morris, E., Atkinson, G., Richardson, R., Lees, J., Caputo, M., Bigotti, G.M., Paul, D.M. (2023) Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio. Journal of muscle research and cell motility. 44(3):179-192
- Cai, W., Wang, Y., Luo, Y., Gao, L., Zhang, J., Jiang, Z., Fan, X., Li, F., Xie, Y., Wu, X., Li, Y., Yuan, W. (2023) asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. International Journal of Molecular Sciences. 24(22):
- He, Y., Wang, Y., Zhu, Y., Lo, L.J. (2023) Loss-of-function of zebrafish cdt1 causes retarded body growth and underdeveloped gonads resembling human Meier-Gorlin syndrome. Journal of Zhejiang University. Science. B. 24:103710461037-1046
- Wu, J., Lin, X., Wu, D., Yan, B., Bao, M., Zheng, P., Wang, J., Yang, C., Li, Z., Jin, X., Jiang, K. (2023) Poly(I:C)-exposed zebrafish shows autism-like behaviors which are ameliorated by fabp2 gene knockout. Frontiers in molecular neuroscience. 15:10680191068019
- Mao, K., Li, X., Chen, Z., Dong, X., Zhangsun, D., Zhu, X., Luo, S. (2022) α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Frontiers in pharmacology. 13:802917
- Li, F., Long, Y., Xie, J., Ren, J., Zhou, T., Song, G., Li, Q., Cui, Z. (2021) Generation of GCaMP6s-Expressing Zebrafish to Monitor Spatiotemporal Dynamics of Calcium Signaling Elicited by Heat Stress. International Journal of Molecular Sciences. 22(11):
- Limonta, G., Mancia, A., Abelli, L., Fossi, M.C., Caliani, I., Panti, C. (2021) Effects of microplastics on head kidney gene expression and enzymatic biomarkers in adult zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 245:109037
- Demin, K.A., Lakstygal, A.M., Krotova, N.A., Masharsky, A., Tagawa, N., Chernysh, M.V., Ilyin, N.P., Taranov, A.S., Galstyan, D.S., Derzhavina, K.A., Levchenko, N.A., Kolesnikova, T.O., Mor, M.S., Vasyutina, M.L., Efimova, E.V., Katolikova, N., Prjibelski, A.D., Gainetdinov, R.R., de Abreu, M.S., Amstislavskaya, T.G., Strekalova, T., Kalueff, A.V. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports. 10:19981
- Tai, Z., Guan, P., Wang, Z., Li, L., Zhang, T., Li, G., Liu, J.X. (2019) Common responses of fish embryos to metals: an integrated analysis of transcriptomes and methylomes in zebrafish embryos under the stress of copper ions or silver nanoparticles. Metallomics : integrated biometal science. 11(9):1452-1464
- Dasgupta, S., Cheng, V., Vliet, S.M.F., Mitchell, C.A., Volz, D.C. (2018) Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis. Environmental science & technology. 52(18):10820-10828
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