Gene
foxg1a
- ID
- ZDB-GENE-990415-267
- Name
- forkhead box G1a
- Symbol
- foxg1a Nomenclature History
- Previous Names
-
- BF-1
- bf1
- foxg1
- brain factor 1
- zgc:109850
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable sequence-specific double-stranded DNA binding activity. Involved in subpallium development. Acts upstream of or within embryonic retina morphogenesis in camera-type eye; neuron differentiation; and nose development. Predicted to be active in nucleus. Is expressed in several structures, including anterior neural keel; anterior neural rod; immature eye; nervous system; and presumptive telencephalon. Orthologous to human FOXG1 (forkhead box G1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 56 figures from 34 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a266 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| sa15987 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23103 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sud24 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| uab454 | Allele with one delins | Promoter | Unknown | not specified |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-foxg1a | (2) | |
| CRISPR2-foxg1a | (2) | |
| CRISPR3-foxg1a | (2) | |
| CRISPR4-foxg1a | (2) | |
| CRISPR5-foxg1a | Umeda et al., 2024 | |
| MO1-foxg1a | N/A | (2) |
| MO2-foxg1a | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Rett syndrome | Alliance | Rett syndrome, congenital variant | 613454 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Family | IPR047208 | Forkhead box protein G1 |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box protein G1 | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:O73862 | InterPro | 420 | ||||||
| UniProtKB:Q568V0 | InterPro | 420 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxg1a-201
(1)
|
Ensembl | 2,336 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28G23 | ||
| Encodes | cDNA | MGC:109850 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131067 (1) | 2348 nt | ||
| Genomic | GenBank:BX511189 (1) | 223248 nt | ||
| Polypeptide | UniProtKB:O73862 (1) | 420 aa |
- Bell, J.M., Turner, E.M., Biesemeyer, C., Vanderbeck, M.M., Hendricks, R., McGraw, H.F. (2024) foxg1a is required for hair cell development and regeneration in the zebrafish lateral line. Biology Open. 13(9):
- Chowdhury, G., Umeda, K., Ohyanagi, T., Nasu, K., Yamasu, K. (2024) Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development. Development, growth & differentiation. 66(2):145-160
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Yang, X., Zhou, W., Zhou, J., Li, A., Zhang, C., Fang, Z., Wang, C., Liu, S., Hao, A., Zhang, M. (2024) Pcgf5: An important regulatory factor in early embryonic neural induction. Heliyon. 10:e27634e27634
- Bulk, J., Kyrychenko, V., Rensinghoff, P.M., Ghaderi Ardekani, Z., Heermann, S. (2023) Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish. International Journal of Molecular Sciences. 24(9):
- Nurcombe, Z.W., Hehr, C.L., McFarlane, S. (2023) Plexina4 and cell survival in the developing zebrafish hindbrain. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(11):1323-1337
- Hehr, C.L., Halabi, R., McFarlane, S. (2022) Spatial regulation of amacrine cell genesis by Semaphorin 3f. Developmental Biology. 491:66-81
- Hernández-Bejarano, M., Gestri, G., Monfries, C., Tucker, L., Dragomir, E.I., Bianco, I.H., Bovolenta, P., Wilson, S.W., Cavodeassi, F. (2022) Foxd1-dependent induction of a temporal retinal character is required for visual function. Development (Cambridge, England). 149(24):
- Cechmanek, P.B., Hehr, C.L., McFarlane, S. (2021) Retinal Pigment Epithelium and Neural Retinal Progenitors Interact Via Semaphorin 6D to Facilitate Optic Cup Morphogenesis. eNeuro. 8(3):
- Ozalp, O., Cark, O., Azbazdar, Y., Haykir, B., Cucun, G., Kucukaylak, I., Alkan-Yesilyurt, G., Sezgin, E., Ozhan, G. (2021) Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis. Biomolecules. 11(1):
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