Gene
ndr1
- ID
- ZDB-GENE-990415-256
- Name
- nodal-related 1
- Symbol
- ndr1 Nomenclature History
- Previous Names
-
- Ndr-1
- CHUNP6892
- sqt
- squint
- Znr-2
- znr2
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Involved in camera-type eye development. Acts upstream of or within several processes, including hypothalamus development; positive regulation of fibroblast growth factor receptor signaling pathway; and regionalization. Part of protein-containing complex. Is expressed in embryonic structure; ovary; posterior lateral line primordium; and unfertilized egg. Human ortholog(s) of this gene implicated in visceral heterotaxy 5. Orthologous to human NODAL (nodal growth differentiation factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 61 figures from 49 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 28 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a175 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| cz35 | Allele with one insertion | Unknown | Unknown | not specified | |
| hi975Tg | Transgenic insertion | Exon 2 | Unknown | DNA | |
| la021868Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| ndr1_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| sg7 | Allele with one insertion | Unknown | Unknown | zinc finger nuclease | |
| sg27 | Allele with one delins | Unknown | Unknown | TALEN | |
| sg32 | Allele with one delins | Unknown | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ndr1 | (2) | |
| CRISPR2-ndr1 | Wu et al., 2018 | |
| CRISPR3-ndr1 | Wu et al., 2018 | |
| CRISPR4-ndr1 | Wu et al., 2018 | |
| CRISPR5-ndr1 | Goudarzi et al., 2019 | |
| CRISPR6-ndr1 | Goudarzi et al., 2019 | |
| CRISPR7-ndr1 | Goudarzi et al., 2019 | |
| MO1-ndr1 | N/A | (3) |
| MO2-ndr1 | N/A | (3) |
| MO3-ndr1 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| visceral heterotaxy 5 | Alliance | Heterotaxy, visceral, 5 | 270100 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|
| UniProtKB:O13144 | InterPro | 392 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(ndr1:GFP) |
|
| 1 | (2) | |
| Tg(UAS:ndr1-UTRnanos3) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-220B15 | ||
| Contained in | BAC | CH211-263M18 | ZFIN Curated Data | |
| Contains | SNP | rs3729101 | ZFIN Curated Data | |
| Contains | SNP | rs3729102 | ZFIN Curated Data | |
| Encodes | BAC END | zk5k12.sp6 | ||
| Encodes | cDNA | MGC:114021 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130966 (1) | 1475 nt | ||
| Genomic | GenBank:BX530056 (1) | 235804 nt | ||
| Polypeptide | UniProtKB:O13144 (1) | 392 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Peng, Y., Shu, L., Deng, X., Huang, X., Mo, X., Du, F., Tang, Z. (2023) Live-Cell Imaging of Endogenous RNA with a Genetically Encoded Fluorogenic Allosteric Aptamer. Analytical chemistry. 95(37):13762-13768
- Kuhn, T., Landge, A.N., Mörsdorf, D., Coßmann, J., Gerstenecker, J., Čapek, D., Müller, P., Gebhardt, J.C.M. (2022) Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model. Nature communications. 13:6101
- Preiß, H., Kögler, A.C., Mörsdorf, D., Čapek, D., Soh, G.H., Rogers, K.W., Morales-Navarrete, H., Almuedo-Castillo, M., Müller, P. (2022) Regulation of Nodal signaling propagation by receptor interactions and positive feedback. eLIFE. 11:
- Wang, Y.Y., Nie, L., Xu, X.X., Shao, T., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Essential Role of RIG-I in Hematopoietic Precursor Emergence in Primitive Hematopoiesis during Zebrafish Development. ImmunoHorizons. 6:283-298
- Xing, C., Shen, W., Gong, B., Li, Y., Yan, L., Meng, A. (2022) Maternal Factors and Nodal Autoregulation Orchestrate Nodal Gene Expression for Embryonic Mesendoderm Induction in the Zebrafish. Frontiers in cell and developmental biology. 10:887987
- Xing, C., Zeng, Z., Li, Y., Gong, B., Shen, W., Shah, R., Yan, L., Du, H., Meng, A. (2022) Regulatory factor identification for nodal genes in zebrafish by causal inference. Frontiers in cell and developmental biology. 10:1047363
- Guglielmi, L., Heliot, C., Kumar, S., Alexandrov, Y., Gori, I., Papaleonidopoulou, F., Barrington, C., East, P., Economou, A.D., French, P.M.W., McGinty, J., Hill, C.S. (2021) Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways. Nature communications. 12:6374
- Hasanpour, S., Eagderi, S., Poorbagher, H., Angrand, P.O., Hasanpour, M., Lashkarbolok, M. (2021) The effect of Activin pathway modulation on the expression of both pluripotency and differentiation markers during early zebrafish development compared with other vertebrates. Journal of experimental zoology. Part B, Molecular and developmental evolution. 336(7):562-575
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