Gene
snai1a
- ID
- ZDB-GENE-990415-255
- Name
- snail family zinc finger 1a
- Symbol
- snai1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables NF-kappaB binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; epithelial to mesenchymal transition; and mesodermal cell migration. Located in nucleus. Is expressed in several structures, including blastodisc; germ ring; mesoderm; pharyngeal arch; and presumptive mesoderm. Orthologous to human SNAI1 (snail family transcriptional repressor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 81 figures from 55 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb643 (78 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010250Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la017795Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la017796Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-snai1a | Wu et al., 2025 | |
| MO1-snai1a | N/A | (2) |
| MO2-snai1a | N/A | (6) |
| MO3-snai1a | N/A | (2) |
| MO4-snai1a | N/A | Park et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Snail/Krueppel C2H2-type Zinc-finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:Q90274 | InterPro | 260 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
snai1a-201
(1)
|
Ensembl | 986 nt | ||
| mRNA |
snai1a-202
(1)
|
Ensembl | 1,942 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:FLAG-dnsnai1a) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-25D12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-232B12 | ZFIN Curated Data | |
| Encodes | EST | cb643 | (2) | |
| Encodes | cDNA | MGC:55277 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109820 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173651 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191765 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001313699 (1) | 1960 nt | ||
| Genomic | GenBank:CR555298 (2) | 183135 nt | ||
| Polypeptide | UniProtKB:Q90274 (1) | 260 aa |
- Deebani, A., Mary, J., Dhinoja, S., Al Qaryoute, A., Fallatah, W., Jagadeeswaran, P. (2025) Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition. Scientific Reports. 15:30583058
- Wu, Q., Xu, J., Tang, X., Yu, J., Li, B., Yang, J., Zhang, X. (2025) SB218078 inhibits angiogenesis and epithelial-mesenchymal transition in breast cancer. Frontiers in pharmacology. 16:15527071552707
- Yu, C., Li, X., Ma, J., Liang, S., Zhao, Y., Li, Q., Zhang, R. (2024) Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration. Cellular and molecular life sciences : CMLS. 81:6060
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- Zhang, J., Li, P., Sun, L., Jiang, N., Guo, W., Wang, J., Gao, F., Li, J., Li, H., Zhang, J., Mu, H., Hu, Y., Cui, X. (2023) Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22927e22927
- Zhao, Y., Wang, H., He, T., Ma, B., Chen, G., Tzeng, C. (2023) Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals. Journal of cell communication and signaling. 17(4):1335-1354
- Casey, M.J., Call, A.M., Thorpe, A.V., Jette, C.A., Engel, M.E., Stewart, R.A. (2022) The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis. iScience. 26:105737105737
- Trengove, M., Wyett, R., Liongue, C., Ward, A.C. (2022) Functional Analysis of Zebrafish socs4a: Impacts on the Notochord and Sensory Function. Brain sciences. 12(2):
- Wasserman, A.H., Huang, A.R., Lewis-Israeli, Y.R., Dooley, M.D., Mitchell, A.L., Venkatesan, M., Aguirre, A. (2022) Oxytocin promotes epicardial cell activation and heart regeneration after cardiac injury. Frontiers in cell and developmental biology. 10:985298
- Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M.R.M., Zangi, L., Betel, D., Cao, J. (2022) Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 13:77047704
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