Gene

rx3

ID
ZDB-GENE-990415-238
Name
retinal homeobox gene 3
Symbol
rx3 Nomenclature History
Previous Names
  • chk
  • chokh
  • eyes missing (1)
  • eym (1)
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including camera-type eye development; diencephalon development; and neural crest cell migration. Predicted to be located in nucleus. Is expressed in several structures, including forebrain; neural keel; neural plate; presumptive neural plate; and retina. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Orthologous to human RAX (retina and anterior neural fold homeobox).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
86 figures from 54 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hu499Allele with one point mutationUnknownMissenseENU
ne2611Allele with one point mutationExon 2MissenseENU
rx3_unspecifiedUnspecified AlleleUnknownUnknownnot specified
s399Allele with one point mutationUnknownPremature StopENU
sa29528Allele with one point mutationUnknownSplice SiteENU
t25181Allele with one point mutationUnknownMissenseENU
t25327Allele with one point mutationUnknownPremature StopENU
w29Allele with one point mutationExon 2Premature StopENU
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Sequence Targeting Reagents
1 - 10 of 28
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Human Disease
Associated With rx3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated microphthalmia 3 Alliance Microphthalmia, syndromic 16 611038
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Associated With rx3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR003654 OAR domain
Family IPR043562 Retinal homeobox protein RAX/RAX2
Homologous_superfamily IPR009057 Homedomain-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length Homedomain-like superfamily Homeobox, conserved site Homeodomain OAR domain Retinal homeobox protein RAX/RAX2
UniProtKB:O42358 InterPro 292
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 21
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA rx3-201 (1) Ensembl 1,411 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(rx3:Kaede)
  • rx3
  • Danio rerio
1Samuel et al., 2016
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-233A1ZFIN Curated Data
EncodescDNAMGC:195183ZFIN Curated Data
EncodescDNAMGC:195186ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanRAX18
Amino acid sequence comparison (2)
Conserved genome location (synteny) (3)
MouseRax18
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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