Gene
fzd2
- ID
- ZDB-GENE-990415-224
- Name
- frizzled class receptor 2
- Symbol
- fzd2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within several processes, including Wnt signaling pathway, calcium modulating pathway; heart development; and sensory epithelium regeneration. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; fin; head; head mesenchyme; and mesoderm. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb383 (18 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028896Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sdu2 | Allele with one deletion | Exon 1 | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fzd2 | N/A | Fong et al., 2005 |
| MO2-fzd2 | N/A | (4) |
| MO3-fzd2 | N/A | (4) |
| TALEN1-fzd2 | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| omodysplasia 2 | Alliance | Omodysplasia 2 | 164745 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Frizzled/Smoothened, 7TM | GPCR, family 2-like, 7TM |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90YL7 | InterPro | 550 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-194J22 | ZFIN Curated Data | |
| Encodes | EST | cb383 | Thisse et al., 2001 | |
| Encodes | EST | fb70g09 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65755 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131140 (1) | 2360 nt | ||
| Genomic | GenBank:CU062431 (2) | 183293 nt | ||
| Polypeptide | UniProtKB:Q90YL7 (1) | 550 aa |
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Fulton, T., Trivedi, V., Attardi, A., Anlas, K., Dingare, C., Arias, A.M., Steventon, B. (2020) Axis Specification in Zebrafish Is Robust to Cell Mixing and Reveals a Regulation of Pattern Formation by Morphogenesis. Current biology : CB. 30(15):2984-2994.e3
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
- Menon, T., Borbora, A.S., Kumar, R., Nair, S. (2020) Dynamic optima in cell sizes during early development enable normal gastrulation in zebrafish embryos. Developmental Biology. 468(1-2):26-40
- Xiong, H., Huang, Y., Mao, Y., Liu, C., Wang, J. (2020) Inhibition in growth and cardiotoxicity of tris (2-butoxyethyl) phosphate through down-regulating Wnt signaling pathway in early developmental stage of zebrafish (Danio rerio). Ecotoxicology and environmental safety. 208:111431
- Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730
- Kamei, C.N., Gallegos, T.F., Liu, Y., Hukriede, N., Drummond, I.A. (2019) Wnt signaling mediates new nephron formation during zebrafish kidney regeneration. Development (Cambridge, England). 146(8):
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Eubelen, M., Bostaille, N., Cabochette, P., Gauquier, A., Tebabi, P., Dumitru, A.C., Koehler, M., Gut, P., Alsteens, D., Stainier, D.Y.R., Garcia-Pino, A., Vanhollebeke, B. (2018) A molecular mechanism for Wnt ligand-specific signaling. Science (New York, N.Y.). 361(6403):
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