Gene
dharma
- ID
- ZDB-GENE-990415-22
- Name
- dharma
- Symbol
- dharma Nomenclature History
- Previous Names
-
- dha (1)
- boz
- bozozok
- momo
- nieuwkoid
- nwk
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including determination of left/right symmetry; nervous system development; and regulation of signal transduction. Predicted to be located in nucleus. Is expressed in embryonic structure.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 68 figures from 53 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-dharma | N/A | Ro et al., 2009 |
MO2-dharma | N/A | (2) |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain |
---|---|---|---|---|---|---|
UniProtKB:O93236 | InterPro | 192 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
dharma-201
(1)
|
Ensembl | 770 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(dharma:GFP) |
|
| 1 | (5) |
1 - 1 of 1
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-188J1 | ZFIN Curated Data | |
Contains | SNP | rs3728729 | ZFIN Curated Data | |
Contains | SNP | rs3728730 | ZFIN Curated Data | |
Contains | SNP | rs3728731 | ZFIN Curated Data | |
Contains | SNP | rs3728732 | ZFIN Curated Data | |
Contains | SNP | rs3728733 | ZFIN Curated Data | |
Contains | SNP | rs3728734 | ZFIN Curated Data | |
Encodes | cDNA | MGC:152854 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192346 | ZFIN Curated Data |
1 - 9 of 9
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_130979 (1) | 833 nt | ||
Genomic | GenBank:CR388133 (1) | 98273 nt | ||
Polypeptide | UniProtKB:O93236 (1) | 192 aa |
No data available
- Li, Y., Yan, Y., Gong, B., Zheng, Q., Zhou, H., Sun, J., Li, M., Wang, Z., Li, Y., Wan, Y., Chen, W., Qi, S., Mo, X., Meng, A., Xiang, B., Chen, J. (2024) A Huluwa phosphorylation switch regulates embryonic axis induction. Nature communications. 15:1002810028
- Miao, D., Ren, J., Jia, Y., Jia, Y., Li, Y., Huang, H., Gao, R. (2024) PAX1 represses canonical Wnt signaling pathway and plays dual roles during endoderm differentiation. Cell communication and signaling : CCS. 22:242242
- Liao, T., Xu, X., Wu, J., Xie, Y., Yan, J. (2023) Increased expression levels of DLX5 inhibit the development of the nervous system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 83(8):728-739
- Zhang, C., Lu, T., Zhang, Y., Li, J., Tarique, I., Wen, F., Chen, A., Wang, J., Zhang, Z., Zhang, Y., Shi, D.L., Shao, M. (2021) Rapid generation of maternal mutants via oocyte transgenic expression of CRISPR-Cas9 and sgRNAs in zebrafish. Science advances. 7(32)
- He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., Sun, Y. (2020) Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLoS Biology. 18:e3000561
- Kesavan, G., Raible, F., Gupta, M., Machate, A., Yilmaz, D., Brand, M. (2020) Isthmin1, a secreted signaling protein, acts downstream of diverse embryonic patterning centers in development. Cell and tissue research. 383(3):987-1002
- Kobayashi, K., Khan, A., Ikeda, M., Nakamoto, A., Maekawa, M., Yamasu, K. (2018) In vitro analysis of the transcriptional regulatory mechanism of zebrafish pou5f3. Experimental cell research. 364(1):28-41
- Niu, J., Guan, J., Li, R., Li, X., Zhai, J., Qi, J., He, Y. (2018) Cynoglossus semilaevis Rspo3 Regulates Embryo Development by Inhibiting the Wnt/β-Catenin Signaling Pathway.. International Journal of Molecular Sciences. 19(7)
- Hino, H., Nakanishi, A., Seki, R., Aoki, T., Yamaha, E., Kawahara, A., Shimizu, T., Hibi, M. (2017) Roles of maternal wnt8a transcripts in axis formation in zebrafish. Developmental Biology. 434(1):96-107
- Kim, H.T., Lee, M.S., Jeong, Y.M., Ro, H., Kim, D.I., Shin, Y.H., Kim, J.E., Hwang, K.S., Choi, J.H., Bahn, M., Lee, J.J., Lee, S.H., Bae, Y.K., Lee, J.S., Choi, J.K., Kim, N.S., Yeo, C.Y., Kim, C.H. (2017) Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. Scientific Reports. 7:13278
1 - 10 of 136
Show