Gene
pax7a
- ID
- ZDB-GENE-990415-201
- Name
- paired box 7a
- Symbol
- pax7a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within developmental pigmentation; regulation of xanthophore differentiation; and wound healing. Located in nucleus. Is expressed in several structures, including central nervous system; muscle; neural crest; neural tube; and post-vent region. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma and congenital myopathy 19. Orthologous to human PAX7 (paired box 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 62 figures from 41 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| oz19 | Allele with one delins | Unknown | Unknown | CRISPR | |
| oz23 | Allele with one delins | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| sa14696 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35152 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41908 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| umu3 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pax7a | Berberoglu et al., 2017 | |
| MO1-pax7a | N/A | (2) |
| TALEN1-pax7a | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alveolar rhabdomyosarcoma | Alliance | Rhabdomyosarcoma 2, alveolar | 268220 |
| congenital myopathy 19 | Alliance | Congenital myopathy 19 | 618578 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired box protein 7, C-terminal | Paired DNA-binding domain | Paired domain | PAX family | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IM38 | InterPro | 487 | |||||||||
| UniProtKB:O57418 | InterPro | 507 | |||||||||
| UniProtKB:A0A8M3B4A0 | InterPro | 502 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(pax7a:EGFP) |
|
| 1 | (6) | |
| TgBAC(pax7a:GFP) |
|
| 1 | (9) | |
| TgBAC(pax7a:LY-Tomato) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-132O13 | ZFIN Curated Data | |
| Contained in | BAC | CH73-220M10 | ZFIN Curated Data | |
| Contained in | BAC | CH211-168O24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195012 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195022 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195043 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195223 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131326 (1) | 2403 nt | ||
| Genomic | GenBank:BX957335 (1) | 168444 nt | ||
| Polypeptide | UniProtKB:O57418 (1) | 507 aa |
- Zhou, C., Li, M., Sun, Y., Sultan, Y., Li, X. (2024) Systematic Identification of Long Noncoding RNAs during Three Key Organogenesis Stages in Zebrafish. International Journal of Molecular Sciences. 25(6):
- Shainer, I., Kuehn, E., Laurell, E., Al Kassar, M., Mokayes, N., Sherman, S., Larsch, J., Kunst, M., Baier, H. (2023) A single-cell resolution gene expression atlas of the larval zebrafish brain. Science advances. 9:eade9909
- Brożko, N., Baggio, S., Lipiec, M.A., Jankowska, M., Szewczyk, Ł.M., Gabriel, M.O., Chakraborty, C., Ferran, J.L., Wiśniewska, M.B. (2022) Genoarchitecture of the Early Postmitotic Pretectum and the Role of Wnt Signaling in Shaping Pretectal Neurochemical Anatomy in Zebrafish. Frontiers in Neuroanatomy. 16:838567
- Watson, C.J., Tang, W.J., Rojas, M.F., Fiedler, I.A.K., Morfin Montes de Oca, E., Cronrath, A.R., Callies, L.K., Swearer, A.A., Ahmed, A.R., Sethuraman, V., Addish, S., Farr, G.H., Gómez, A.E., Rai, J., Monstad-Rios, A.T., Gardiner, E.M., Karasik, D., Maves, L., Busse, B., Hsu, Y.H., Kwon, R.Y. (2022) wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. PLoS Genetics. 18:e1010496
- Hung, J.C., Wu, J.L., Hong, J.R. (2021) Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Hung, J.C., Wu, J.L., Li, H.C., Chiu, H.W., Hong, J.R. (2021) The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish. Cells. 10(11):
- In Ka, H., Seo, H., Choi, Y., Kim, J., Cho, M., Choi, S.Y., Park, S., Han, S., An, J., Chung, H.S., Yang, Y., Kim, M.J. (2021) Loss of splicing factor IK impairs normal skeletal muscle development. BMC Biology. 19:44
- Lencer, E., Prekeris, R., Artinger, K.B. (2021) Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives. eLIFE. 10:
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Nord, H., Kahsay, A., Dennhag, N., Pedrosa Domellöf, F., von Hofsten, J. (2021) Genetic compensation between Pax3 and Pax7 in zebrafish appendicular muscle formation. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(9):1423-1438
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