Gene
atoh1a
- ID
- ZDB-GENE-990415-17
- Name
- atonal bHLH transcription factor 1a
- Symbol
- atoh1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables chromatin binding activity. Acts upstream of or within mechanoreceptor differentiation. Predicted to be active in nucleus. Is expressed in hindbrain neural keel; nervous system; neural tube; otic epithelium; and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 89. Orthologous to human ATOH1 (atonal bHLH transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 115 figures from 75 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| atoh1a_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh282 | Allele with one point mutation | Unknown | Unknown | ENU | |
| ihb543 | Allele with one insertion | Exon 1 | Unknown | CRISPR | |
| ihb544 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| w214Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| w259Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-atoh1a | (3) | |
| CRISPR2-atoh1a | Navajas Acedo et al., 2019 | |
| CRISPR3-atoh1a | Navajas Acedo et al., 2019 | |
| CRISPR4-atoh1a | Zebrafish Nomenclature Committee | |
| MO1-atoh1a | N/A | (2) |
| MO2-atoh1a | N/A | (4) |
| MO3-atoh1a | N/A | Millimaki et al., 2007 |
| MO4-atoh1a | N/A | (7) |
| MO5-atoh1a | N/A | Sassa et al., 2007 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 89 | Alliance | ?Deafness, autosomal dominant 89 | 620284 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR032661 | Transcription factor ATOH1, basic helix-loop-helix domain |
| Family | IPR050359 | Basic helix-loop-helix transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Transcription factor ATOH1, basic helix-loop-helix domain |
|---|---|---|---|---|---|---|
| UniProtKB:B0R059 | InterPro | 292 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atoh1a-201
(1)
|
Ensembl | 1,630 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(atoh1a:dTomato) |
|
| 1 | (23) | |
| Tg(atoh1a:EGFP) |
|
| 1 | (8) | |
| Tg(atoh1a:GAL4TA4) |
|
| 1 | (12) | |
| Tg(hsp70l:atoh1a) |
|
| 1 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-247L22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136417 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131091 (1) | 1638 nt | ||
| Genomic | GenBank:AL807792 (1) | 160553 nt | ||
| Polypeptide | UniProtKB:B0R059 (1) | 292 aa |
- Castranova, D., Kenton, M.I., Kraus, A., Dell, C.W., Park, J.S., Venero Galanternik, M., Park, G., Lumbantobing, D.N., Dye, L., Marvel, M., Iben, J., Taimatsu, K., Pham, V., Willms, R.J., Blevens, L., Robertson, T.F., Hou, Y., Huttenlocher, A., Foley, E., Parenti, L.R., Frazer, J.K., Narayan, K., Weinstein, B.M. (2025) The axillary lymphoid organ is an external, experimentally accessible immune organ in the zebrafish. The Journal of experimental medicine. 222:
- Dicipulo, R., Selland, L.G., Carpenter, R.G., Waskiewicz, A.J. (2025) Functional role for Taz during hindbrain ventricle morphogenesis. PLoS One. 20:e0313262e0313262
- Sobah, M.L., Liongue, C., Ward, A.C. (2025) Socs3a is Dispensable for Zebrafish Hematopoiesis and is Required for Neuromast Formation. Frontiers in bioscience (Landmark edition). 30:3653736537
- Bell, J.M., Turner, E.M., Biesemeyer, C., Vanderbeck, M.M., Hendricks, R., McGraw, H.F. (2024) foxg1a is required for hair cell development and regeneration in the zebrafish lateral line. Biology Open. 13(9):
- Itoh, T., Uehara, M., Yura, S., Wang, J.C., Fujii, Y., Nakanishi, A., Shimizu, T., Hibi, M. (2024) Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish. Development (Cambridge, England). 151(7):
- Olson, H.M., Maxfield, A., Calistri, N.L., Heiser, L.M., Qian, W., Knaut, H., Nechiporuk, A.V. (2024) RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration. Development (Cambridge, England). 151(1):
- Brown, T.L., Horton, E.C., Craig, E.W., Goo, C.E.A., Black, E.C., Hewitt, M.N., Yee, N.G., Fan, E.T., Raible, D.W., Rasmussen, J.P. (2023) Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells. eLIFE. 12:
- Ezhkova, D., Schwarzer, S., Spieß, S., Geffarth, M., Machate, A., Zöller, D., Stucke, J., Alexopoulou, D., Lesche, M., Dahl, A., Hans, S. (2023) Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Biology Open. 12(6):
- Megerson, E., Kuehn, M., Leifer, B., Bell, J.M., Snyder, J.L., McGraw, H.F. (2023) Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line. iScience. 27:108678108678
- Shi, T., Beaulieu, M.O., Saunders, L.M., Fabian, P., Trapnell, C., Segil, N., Crump, J.G., Raible, D.W. (2023) Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. eLIFE. 12:
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