Gene
spon2b
- ID
- ZDB-GENE-990415-161
- Name
- spondin 2b, extracellular matrix protein
- Symbol
- spon2b Nomenclature History
- Previous Names
-
- etID309958.14 (1)
- mindin2
- zgc:100756
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Predicted to be involved in cell adhesion. Located in extracellular matrix. Is expressed in floor plate; hypochord; mesenchymal cell; and notochord. Orthologous to human SPON2 (spondin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22444 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009465 | Spondin, N-terminal |
| Domain | IPR044004 | Spondin-like TSP1 domain |
| Family | IPR051418 | Spondin/Thrombospondin type-1 domain-containing |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Homologous_superfamily | IPR038678 | Spondin, N-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Spondin-like TSP1 domain | Spondin, N-terminal | Spondin, N-terminal domain superfamily | Spondin/Thrombospondin type-1 domain-containing | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q0V935 | InterPro | 331 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
spon2b-201
(1)
|
Ensembl | 2,118 nt | ||
| mRNA |
spon2b-202
(1)
|
Ensembl | 1,633 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-255I20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:100756 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152813 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192396 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131008 (1) | 1337 nt | ||
| Genomic | GenBank:BX005356 (1) | 171108 nt | ||
| Polypeptide | UniProtKB:Q0V935 (1) | 331 aa |
- Askary, A., Xu, P., Barske, L., Bay, M., Bump, P., Balczerski, B., Bonaguidi, M.A., Crump, J.G. (2017) Genome-wide analysis of facial skeletal regionalization in zebrafish. Development (Cambridge, England). 144(16):2994-3005
- Zhou, X., Yue, G.G., Liu, M., Zuo, Z., Lee, J.K., Li, M., Tsui, S.K., Fung, K.P., Sun, H., Pu, J., Lau, C.B. (2016) Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling. Oncotarget. 7(50):82820-82835
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Desai, S., Heffelfinger, A.K., Orcutt, T.M., Litman, G.W., and Yoder, J.A. (2008) The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains. BMC Evolutionary Biology. 8:177
- Norton, W.H., Mangoli, M., Lele, Z., Pogoda, H.M., Diamond, B., Mercurio, S., Russell, C., Teraoka, H., Stickney, H.L., Rauch, G.J., Heisenberg, C.P., Houart, C., Schilling, T.F., Frohnhoefer, H.G., Rastegar, S., Neumann, C.J., Gardiner, R.M., Strähle, U., Geisler, R., Rees, M., Talbot, W.S., and Wilson, S.W. (2005) Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones. Development (Cambridge, England). 132(4):645-658
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Higashijima, S., Nose, A., Eguchi, G., Hotta, Y., and Okamoto, H. (1997) Mindin/F-spondin family: novel ECM proteins expressed in the zebrafish embryonic axis. Developmental Biology. 192:211-227
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