Gene
mtnr1ba
- ID
- ZDB-GENE-990415-157
- Name
- melatonin receptor type 1Ba
- Symbol
- mtnr1ba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in diencephalic nucleus; male organism; and midbrain. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (melatonin receptor 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, type 2, susceptibility to} | 125853 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Melatonin receptor 1A/1B | Melatonin receptor family |
|---|---|---|---|---|---|---|
| UniProtKB:B3DJ99 | InterPro | 355 | ||||
| UniProtKB:Q90456 | InterPro | 287 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mtnr1ba-201
(1)
|
Ensembl | 1,260 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-310J8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-109F24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194859 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194890 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131395 (1) | 1260 nt | ||
| Genomic | GenBank:CR524482 (2) | 125769 nt | ||
| Polypeptide | UniProtKB:B3DJ99 (1) | 355 aa |
- Lutfi, E., Basili, D., Falcinelli, S., Morillas, L., Carnevali, O., Capilla, E., Navarro, I. (2021) The probiotic Lactobacillus rhamnosus mimics the dark-driven regulation of appetite markers and melatonin receptors' expression in zebrafish (Danio rerio) larvae: Understanding the role of the gut microbiome. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 256:110634
- Li, Y., Lv, Y., Bian, C., You, X., Shi, Q. (2020) Molecular evolution of melatonin receptor genes (mtnr) in vertebrates and its shedding light on mtnr1c. Gene. 769:145256
- Maugars, G., Nourizadeh-Lillabadi, R., Weltzien, F.A. (2020) New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Frontiers in endocrinology. 11:538196
- Loganathan, K., Moriya, S., Parhar, I.S. (2019) Diurnal Rhythm of trek2a Expression is Associated with Diurnal Rhythm of gnrh3 Expression in Zebrafish. Zoological science. 36:167-171
- Üstündağ, Ü.V., Çalıskan-Ak, E., Ateş, P.S., Ünal, İ., Eğilmezer, G., Yiğitbaşı, T., Ata Alturfan, A., Emekli-Alturfan, E. (2019) White LED Light Exposure Inhibits the Development and Xanthophore Pigmentation of Zebrafish Embryo. Scientific Reports. 9:10810
- Loganathan, K., Moriya, S., Parhar, I.S. (2018) High Melatonin Conditions by Constant Darkness and High Temperature Differently Affect Melatonin Receptor mt1 and TREK Channel trek2a in the Brain of Zebrafish. Zebrafish. 15(5):473-483
- Ribas, L., Vanezis, K., Imués, M.A., Piferrer, F. (2017) Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads. Epigenetics & chromatin. 10:59
- Villarreal, M.A., Biediger, N.M., Bonner, N.A., Miller, J.N., Zepeda, S.K., Ricard, B.J., García, D.M., Lewis, K.A. (2017) Determining Zebrafish Epitope Reactivity to Commercially Available Antibodies. Zebrafish. 14(4):387-389
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Ren, D.L., Sun, A.A., Li, Y.J., Chen, M., Ge, S.C., Hu, B. (2015) Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation. The Journal of endocrinology. 227(1):49-60
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