Gene
mtnr1ba
- ID
- ZDB-GENE-990415-157
- Name
- melatonin receptor type 1Ba
- Symbol
- mtnr1ba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within rhythmic process and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in diencephalic nucleus; male organism; and midbrain. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (melatonin receptor 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, type 2, susceptibility to} | 125853 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Melatonin receptor 1A/1B | Melatonin receptor family |
|---|---|---|---|---|---|---|
| UniProtKB:B3DJ99 | InterPro | 355 | ||||
| UniProtKB:Q90456 | InterPro | 287 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mtnr1ba-201
(1)
|
Ensembl | 1,260 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-310J8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-109F24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194859 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194890 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131395 (1) | 1260 nt | ||
| Genomic | GenBank:CR524482 (2) | 125769 nt | ||
| Polypeptide | UniProtKB:B3DJ99 (1) | 355 aa |
- Lutfi, E., Basili, D., Falcinelli, S., Morillas, L., Carnevali, O., Capilla, E., Navarro, I. (2021) The probiotic Lactobacillus rhamnosus mimics the dark-driven regulation of appetite markers and melatonin receptors' expression in zebrafish (Danio rerio) larvae: Understanding the role of the gut microbiome. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 256:110634
- Li, Y., Lv, Y., Bian, C., You, X., Shi, Q. (2020) Molecular evolution of melatonin receptor genes (mtnr) in vertebrates and its shedding light on mtnr1c. Gene. 769:145256
- Maugars, G., Nourizadeh-Lillabadi, R., Weltzien, F.A. (2020) New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Frontiers in endocrinology. 11:538196
- Loganathan, K., Moriya, S., Parhar, I.S. (2019) Diurnal Rhythm of trek2a Expression is Associated with Diurnal Rhythm of gnrh3 Expression in Zebrafish. Zoological science. 36:167-171
- Üstündağ, Ü.V., Çalıskan-Ak, E., Ateş, P.S., Ünal, İ., Eğilmezer, G., Yiğitbaşı, T., Ata Alturfan, A., Emekli-Alturfan, E. (2019) White LED Light Exposure Inhibits the Development and Xanthophore Pigmentation of Zebrafish Embryo. Scientific Reports. 9:10810
- Loganathan, K., Moriya, S., Parhar, I.S. (2018) High Melatonin Conditions by Constant Darkness and High Temperature Differently Affect Melatonin Receptor mt1 and TREK Channel trek2a in the Brain of Zebrafish. Zebrafish. 15(5):473-483
- Ribas, L., Vanezis, K., Imués, M.A., Piferrer, F. (2017) Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads. Epigenetics & chromatin. 10:59
- Villarreal, M.A., Biediger, N.M., Bonner, N.A., Miller, J.N., Zepeda, S.K., Ricard, B.J., García, D.M., Lewis, K.A. (2017) Determining Zebrafish Epitope Reactivity to Commercially Available Antibodies. Zebrafish. 14(4):387-389
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Ren, D.L., Sun, A.A., Li, Y.J., Chen, M., Ge, S.C., Hu, B. (2015) Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation. The Journal of endocrinology. 227(1):49-60
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