Gene
ldb2a
- ID
- ZDB-GENE-990415-136
- Name
- LIM domain binding 2a
- Symbol
- ldb2a Nomenclature History
- Previous Names
-
- ldb2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables chromatin binding activity. Acts upstream of or within negative regulation of BMP signaling pathway; negative regulation of nodal signaling pathway; and sprouting angiogenesis. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including blood island; cardiovascular system; nervous system; posterior lateral mesoderm; and yolk syncytial layer. Orthologous to human LDB2 (LIM domain binding 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la027568Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa35760 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
um91 | Allele with one insertion | Unknown | Frameshift, Premature Stop | zinc finger nuclease | |
um93 | Allele with one deletion | Exon 1 | Splice Site | zinc finger nuclease |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-ldb2a | N/A | Gu et al., 2015 |
MO2-ldb2a | N/A | Gu et al., 2015 |
MO3-ldb2a | N/A | Choi et al., 2017 |
MO4-ldb2a | N/A | Choi et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | LIM-domain binding protein/SEUSS | LIM interaction domain |
---|---|---|---|---|
UniProtKB:A0A8M2B3G5 | InterPro | 387 | ||
UniProtKB:O73713 | InterPro | 385 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-17B5 | ZFIN Curated Data | |
Contained in | BAC | CH211-46C16 | ZFIN Curated Data | |
Contained in | BAC | CH211-186M20 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131314 (1) | 1596 nt | ||
Genomic | GenBank:CU855906 (2) | 104473 nt | ||
Polypeptide | UniProtKB:A0A8M2B3G5 (1) | 387 aa |
- Madera, D., Alonso-Gómez, A., Delgado, M.J., Valenciano, A.I., Alonso-Gómez, Á.L. (2023) Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. International Journal of Molecular Sciences. 25(1):
- Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
- Li, Y., Sun, S., Ding, Z., Yang, C., Zhang, G., Jiang, Q., Zou, Y. (2018) Temporal and spatial expression of fgfbp genes in zebrafish. Gene. 659:128-136
- Choi, H.J., Rho, S.S., Choi, D.H., Kwon, Y.G. (2017) LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells. BMB reports. 51(1):21-26
- Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gu, W., Monteiro, R., Zuo, J., Simões, F.C., Martella, A., Andrieu-Soler, C., Grosveld, F., Sauka-Spengler, T., Patient, R. (2015) A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback. PLoS Biology. 13:e1002051
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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