Gene
hoxc10a
- ID
- ZDB-GENE-990415-110
- Name
- homeobox C10a
- Symbol
- hoxc10a Nomenclature History
- Previous Names
-
- hoxc10
- z-81
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including margin; mesoderm; neuroectoderm; oocyte; and tail bud. Orthologous to human HOXC10 (homeobox C10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028560Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa44032 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein Hox-A10/abdominal-B-like | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P4Z2 | InterPro | 116 | |||||
| UniProtKB:A2BE66 | InterPro | 327 | |||||
| UniProtKB:F6NI81 | InterPro | 337 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| antisense |
ottdart00000059827
(1)
|
Ensembl | 3,057 nt | ||
| mRNA |
hoxc10a-201
(1)
|
Ensembl | 1,601 nt | ||
| mRNA |
hoxc10a-202
(1)
|
Ensembl | 1,242 nt | ||
| mRNA |
hoxc10a-203
(1)
|
Ensembl | 1,769 nt | ||
| mRNA |
hoxc10a-204
(1)
|
Ensembl | 1,872 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-81P22 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001254944 (1) | 1601 nt | ||
| Genomic | GenBank:BX005254 (1) | 160012 nt | ||
| Polypeptide | UniProtKB:F6NI81 (1) | 337 aa |
- Adachi, U., Koita, R., Seto, A., Maeno, A., Ishizu, A., Oikawa, S., Tani, T., Ishizaka, M., Yamada, K., Satoh, K., Nakazawa, H., Furudate, H., Kawakami, K., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Teleost Hox code defines regional identities competent for the formation of dorsal and anal fins. Proceedings of the National Academy of Sciences of the United States of America. 121:e2403809121e2403809121
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Xue, S., Ly, T.T.N., Vijayakar, R.S., Chen, J., Ng, J., Mathuru, A.S., Magdinier, F., Reversade, B. (2022) HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring. Nature communications. 13:3583
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
- Payumo, A.Y., McQuade, L.E., Walker, W.J., Yamazoe, S., Chen, J.K. (2016) Tbx16 regulates hox gene activation in mesodermal progenitor cells. Nature Chemical Biology. 12(9):694-701
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hayward, A.G., Joshi, P., Skromne, I. (2015) Spatiotemporal analysis of zebrafish hox gene regulation by Cdx4. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(12):1564-73
- Tanaka, M., Yu, R., Kurokawa, D. (2015) Anterior migration of lateral plate mesodermal cells during embryogenesis of the pufferfish Takifugu niphobles: insight into the rostral positioning of pelvic fins. Journal of anatomy. 227(1):81-88
- Junker, J.P., Noël, E.S., Guryev, V., Peterson, K.A., Shah, G., Huisken, J., McMahon, A.P., Berezikov, E., Bakkers, J., van Oudenaarden, A. (2014) Genome-wide RNA Tomography in the Zebrafish Embryo. Cell. 159:662-75
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