Gene
hbaa1
- ID
- ZDB-GENE-980526-79
- Name
- hemoglobin, alpha adult 1
- Symbol
- hbaa1 Nomenclature History
- Previous Names
-
- AA1
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and oxygen carrier activity. Acts upstream of or within response to hypoxia. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in eye; hematopoietic system; kidney; presumptive blood; and vasculature. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBA1 (hemoglobin subunit alpha 1) and HBZ (hemoglobin subunit zeta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55446 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
alpha thalassemia | Alliance | Thalassemias, alpha- | 604131 |
familial erythrocytosis 7 | Alliance | Erythrocytosis, familial, 7 | 617981 |
Heinz body anemia | Alliance | Heinz body anemias, alpha- | 140700 |
hemoglobin H disease | Alliance | Hemoglobin H disease, nondeletional | 613978 |
Methemoglobinemia, alpha type | 617973 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Globin | Globin-like superfamily | Globin/Protoglobin | Hemoglobin, alpha-type | Hemoglobin and related oxygen transporters | Hemoglobin, pi |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q803Z5 | InterPro | 143 | ||||||
UniProtKB:Q90487 | InterPro | 143 | ||||||
UniProtKB:Q1JQ69 | InterPro | 143 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hbaa1-201
(1)
|
Ensembl | 651 nt | ||
mRNA | ottdart00000002411 (1) | Havana | 581 nt | ||
mRNA | ottdart00000002413 (1) | Havana | 581 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-5K11 | ZFIN Curated Data | |
Contained in | PAC | BUSM1-118J2 | ||
Encodes | EST | fq14e12 | Rauch et al., 2003 | |
Encodes | cDNA | MGC:55446 | ZFIN Curated Data | |
Encodes | cDNA | MGC:136224 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191622 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131257 (1) | 584 nt | ||
Genomic | GenBank:AL929176 (1) | 100902 nt | ||
Polypeptide | UniProtKB:Q1JQ69 (1) | 143 aa |
- Gimenez, G., Kalev-Zylinska, M.L., Morison, I., Bohlander, S.K., Horsfield, J.A., Antony, J. (2024) Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish. American journal of physiology. Cell physiology. 328(1):C9-C19
- Wang, H., Siren, J., Perttunen, S., Immonen, K., Chen, Y.C., Narumanchi, S., Kosonen, R., Paavola, J., Laine, M., Tikkanen, I., Lakkisto, P. (2024) Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Journal of Cellular and Molecular Medicine. 28:e18243e18243
- Xie, L., Tao, Y., Shen, Z., Deng, H., Duan, X., Xue, Y., Chen, D., Li, Y. (2023) Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology. 151:105108
- Morrison, J.K., DeRossi, C., Alter, I.L., Nayar, S., Giri, M., Zhang, C., Cho, J.H., Chu, J. (2022) Single-cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver. Hepatology communications. 6(7):1711-1724
- Qian, P., Kang, J., Liu, D., Xie, G. (2022) Single Cell Transcriptome Sequencing of Zebrafish Testis Revealed Novel Spermatogenesis Marker Genes and Stronger Leydig-Germ Cell Paracrine Interactions. Frontiers in genetics. 13:851719
- Ragsdale, A., Ortega-Recalde, O., Dutoit, L., Besson, A.A., Chia, J.H.Z., King, T., Nakagawa, S., Hickey, A., Gemmell, N.J., Hore, T., Johnson, S.L. (2022) Paternal hypoxia exposure primes offspring for increased hypoxia resistance. BMC Biology. 20:185
- Belmonte, R.L., Engbretson, I.L., Kim, J.H., Cajias, I., Ahn, E.E., Stachura, D.L. (2021) son is necessary for proper vertebrate blood development. PLoS One. 16:e0247489
- Kim, S.H., Yang, D., Bae, Y.A. (2021) Hypoxic and nitrosative stress conditions modulate expression of myoglobin genes in a carcinogenic hepatobiliary trematode, Clonorchis sinensis. PLoS neglected tropical diseases. 15:e0009811
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Petrova, N.V., Klimenko, N.S., Kovina, A.P., Ioudinkova, E.S., Gavrilov, A.A., Iarovaia, O.V., Razin, S.V. (2020) Mechanisms mediating suppression of globin gene transcription in Danio rerio nonerythroid cells. Biochimie. 181:96-99
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