Gene
klf1
- ID
- ZDB-GENE-980526-55
- Name
- Kruppel like factor 1 (erythroid)
- Symbol
- klf1 Nomenclature History
- Previous Names
-
- klfd
- zgc:194069
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ regeneration; cardiac muscle tissue development; and sarcomere organization. Acts upstream of or within positive regulation of gene expression; primitive erythrocyte differentiation; and regulation of primitive erythrocyte differentiation. Located in chromatin. Is expressed in blood; hematopoietic cell; intermediate cell mass of mesoderm; kidney; and posterior lateral plate mesoderm. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IVa and congenital dyserythropoietic anemia type IVb. Orthologous to human KLF1 (KLF transcription factor 1); KLF17 (KLF transcription factor 17); and KLF18 (KLF transcription factor 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu650 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-klf1 | Suzuki et al., 2023 | |
| CRISPR2-klf1 | Suzuki et al., 2023 | |
| MO1-klf1 | N/A | (2) |
| TALEN1-klf1 | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital dyserythropoietic anemia type IVa | Alliance | Anemia, dyserythropoietic congenital, type IVa | 613673 |
| congenital dyserythropoietic anemia type IVb | Alliance | Anemia, congenital dyserythropoietic, type IVb | 620969 |
| Blood group--Lutheran inhibitor | 111150 | ||
| [Hereditary persistence of fetal hemoglobin] | 613566 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
| UniProtKB:Q90XE6 | InterPro | 365 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:LOXP-TagBFP-STOP-LOXP-3xHA-klf1) |
| 1 | (3) | ||
| Tg(actb2:LOXP-TagBFP-STOP-LOXP-dnklf1) |
| 1 | (3) | ||
| Tg(gata1a:EGFP-UTR-klfd) |
| 10 | (2) | ||
| Tg(myl7:3xHA-klf1-ER,-1kbmyl7:TagBFP) |
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207J7 | ZFIN Curated Data | |
| Encodes | EST | eu650 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:194054 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194069 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130936 (1) | 2532 nt | ||
| Genomic | GenBank:BX601645 (2) | 223513 nt | ||
| Polypeptide | UniProtKB:Q90XE6 (1) | 365 aa |
- Gimenez, G., Kalev-Zylinska, M.L., Morison, I., Bohlander, S.K., Horsfield, J.A., Antony, J. (2024) Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish. American journal of physiology. Cell physiology. 328(1):C9-C19
- Han, X., He, W., Liang, D., Liu, X., Zhou, J., de Thé, H., Zhu, J., Yuan, H. (2024) Creg1 Regulates Erythroid Development via TGF-β/Smad2-Klf1 Axis in Zebrafish. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(33):e2402804
- Pomreinke, A.P., Müller, P. (2024) Zebrafish nampt-a mutants are viable despite perturbed primitive hematopoiesis. Hereditas. 161:1414
- Wang, H., Siren, J., Perttunen, S., Immonen, K., Chen, Y.C., Narumanchi, S., Kosonen, R., Paavola, J., Laine, M., Tikkanen, I., Lakkisto, P. (2024) Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Journal of Cellular and Molecular Medicine. 28:e18243e18243
- Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):
- Suzuki, H., Ogawa, T., Fujita, S., Sone, R., Kawahara, A. (2023) Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis. Scientific Reports. 13:1227912279
- Xie, L., Tao, Y., Shen, Z., Deng, H., Duan, X., Xue, Y., Chen, D., Li, Y. (2023) Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology. 151:105108
- Ogawa, M., Geng, F.S., Humphreys, D.T., Kristianto, E., Sheng, D.Z., Hui, S.P., Zhang, Y., Sugimoto, K., Nakayama, M., Zheng, D., Hesselson, D., Hodson, M.P., Bogdanovic, O., Kikuchi, K. (2021) Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish. Science (New York, N.Y.). 372:201-205
- Ding, Y., Wang, W., Ma, D., Liang, G., Kang, Z., Xue, Y., Zhang, Y., Wang, L., Heng, J., Zhang, Y., Liu, F. (2020) Smarca5 mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood. 137(2):190-202
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
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