Gene
her4.1
- ID
- ZDB-GENE-980526-521
- Name
- hairy-related 4, tandem duplicate 1
- Symbol
- her4.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables double-stranded DNA binding activity. Acts upstream of or within several processes, including Notch signaling pathway; nervous system development; and somite specification. Predicted to be active in nucleus. Is expressed in several structures, including anterior neural rod; embryonic structure; nervous system; neural keel; and segmental plate.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 117 figures from 73 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Hairy and Enhancer of Split/HEY-related | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Orange domain |
---|---|---|---|---|---|---|
UniProtKB:Q90466 | InterPro | 152 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
her4.1-201
(1)
|
Ensembl | 963 nt |
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Interactions and Pathways
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(her4.1:mCherry,Cre-ERT2) |
|
| 3 | (13) | |
Tg(her4.1:TETA-GBD-2A-mCherry) |
|
| 2 | (7) | |
Tg2(her4.1:mCherry) |
|
| 1 | Admati et al., 2019 | |
Tg(her4.1:Cas9-H2B-HaloTag-gRNA-2switch) |
|
| 1 | Espinosa-Medina et al., 2022 | |
Tg(her4.1:GCaMP6m) |
|
| 1 | Zebrafish Nomenclature Committee | |
Tg(her4.1:h2az2a-mCherry) |
|
| 1 | (2) | |
Tg(her4.1:jupa-EGFP) |
|
| 1 | (2) | |
Tg(her4.1:mCherry) |
|
| 1 | Sarangdhar et al., 2018 | |
Tg(her4.1:NTR-KikGR) |
|
| 1 | (3) | |
Tg(her4.1:RTTA,myl7:EGFP) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-21G5 | ZFIN Curated Data | |
Encodes | EST | bn0aa072zb08 | ZFIN Curated Data | |
Encodes | EST | fq41c06 | Rauch et al., 2003 | |
Encodes | cDNA | MGC:173865 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192073 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001103128 (1) | 998 nt | ||
Genomic | GenBank:CU062502 (1) | 62011 nt | ||
Polypeptide | UniProtKB:Q90466 (1) | 152 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Mouse | Hes5 | 4 | Amino acid sequence comparison (1) |
- Bell, J.M., Turner, E.M., Biesemeyer, C., Vanderbeck, M.M., Hendricks, R., McGraw, H.F. (2024) foxg1a is required for hair cell development and regeneration in the zebrafish lateral line. Biology Open. 13(9):
- Bludau, O., Weber, A., Bosak, V., Kuscha, V., Dietrich, K., Hans, S., Brand, M. (2024) Inflammation is a critical factor for successful regeneration of the adult zebrafish retina in response to diffuse light lesion. Frontiers in cell and developmental biology. 12:13323471332347
- Chen, H.Y., Huang, Y.C., Yeh, T.H., Chang, C.W., Shen, Y.J., Chen, Y.C., Sun, M.Q., Cheng, Y.C. (2024) Dtx2 deficiency induces ependymo-radial glial cell proliferation and improves spinal cord motor function recovery. Stem cells and development. 33(19-20):540-550
- Chen, Y.C., Hsieh, F.Y., Chang, C.W., Sun, M.Q., Cheng, Y.C. (2024) Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment. International Journal of Molecular Sciences. 25(17):
- Fernezelian, D., Pfitsch, S., Rastegar, S., Diotel, N. (2024) Mapping the cellular expression patterns of vascular endothelial growth factor aa and bb genes and their receptors in the adult zebrafish brain during constitutive and regenerative neurogenesis. Neural Development. 19:1717
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Park, J.W., Choi, T.I., Kim, T.Y., Lee, Y.R., Don, D.W., George-Abraham, J.K., Robak, L.A., Trandafir, C.C., Liu, P., Rosenfeld, J.A., Kim, T.H., Petit, F., Kim, Y.M., Cheon, C.K., Lee, Y., Kim, C.H. (2024) RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model. Journal of genetics and genomics = Yi chuan xue bao. 51(12):1389-1403
- Roychaudhury, A., Lee, Y.R., Choi, T.I., Thomas, M.G., Kahn, T.N., Yousaf, H., Skinner, C., Maconachie, G., Crosier, M., Horak, H., Constantinescu, C.S., Kim, T.Y., Lee, K.H., Kyung, J.J., Wang, T., Ku, B., Chodirker, B.N., Hammer, M.F., Gottlob, I., Norton, W.H.J., Gorlei, R., Kim, H.G., Graziano, C., Pippucci, T., Lovino, E., Montanari, F., Severi, G., Toro, C., Boerkoel, C.F., Cha, H.S., Choi, C.Y., Kim, S., Yoon, J.Y., Gilmore, K., Vora, N.L., Davis, E.E., Chudley, A.E., Schwartz, C.E., and Kim, C.H. (2024) SRPK3 Is Essential for Cognitive and Ocular Development in Humans and Zebrafish, Explaining X-Linked Intellectual Disability. Annals of neurology. 96(5):914-931
- Luo, Y., Lu, D., Zhou, J., Wu, J., Wang, W., Qian, L. (2023) Milk fat globule epidermal growth factor 8a regulates neurogenesis in telencephalon and affects larval behavior in zebrafish. Stem cells and development. 32(9-10):246-257
- Mizoguchi, T., Okita, M., Minami, Y., Fukunaga, M., Maki, A., Itoh, M. (2023) Age-dependent dysfunction of the cerebrovascular system in the zebrafish telencephalon. Experimental gerontology. 178:112206
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