Gene
fli1
- ID
- ZDB-GENE-980526-426
- Name
- Fli-1 proto-oncogene, ETS transcription factor
- Symbol
- fli1 Nomenclature History
- Previous Names
-
- fli-1
- fli1
- fli1a
- fli
- cb855 (1)
- wu:fc45b11
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within angiogenesis and positive regulation of DNA-binding transcription factor activity. Predicted to be active in nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; hematopoietic system; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor).
- Genome Resources
- Note
-
This gene is orthologous to Fli-1 proto-oncogene, ETS transcription factor, but analyses indicate that the ancestral gene was duplicated prior to the divergence of ray- and lobe-fin fishes and not the result of the WGD event in the ray-fin fishes, so the gene name has been updated to fli1.
- Comparative Information
-
- All Expression Data
- 210 figures from 144 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb855 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Liu et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cig7Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| is10Gt | Transgenic insertion | Intron 3 | Unknown | DNA | |
| md75Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa43180 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| t26394 | unknown | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fli1 | Luo et al., 2018 | |
| CRISPR2-fli1 | Collins et al., 2020 | |
| MO1-fli1 | N/A | Pham et al., 2007 |
| MO2-fli1 | N/A | (4) |
| MO3-fli1 | N/A | O'Meara et al., 2021 |
| MO4-fli1 | N/A | O'Meara et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bleeding disorder, platelet-type, 21 | 617443 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ets domain | ETS family | Friend leukemia integration 1 transcription factor, pointed domain | Pointed domain | Sterile alpha motif/pointed domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P9W7 | InterPro | 465 | |||||||
| UniProtKB:A0A2R8QGN6 | InterPro | 460 | |||||||
| UniProtKB:A0A8M9PF94 | InterPro | 456 | |||||||
| UniProtKB:A0A8M9PLW9 | InterPro | 474 | |||||||
| UniProtKB:Q9PU61 | InterPro | 451 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fli1:EGFP) |
|
| 3 | (1860) | |
| Tg(fli1.ep:DsRedEx) |
|
| 1 | (58) | |
| Tg(fli1:GAL4FF) |
|
| 3 | (97) | |
| Tg(fli1:nEGFP) |
|
| 1 | (227) | |
| Tg1(fli1:mCherry) |
|
| Zebrafish Nomenclature Committee | ||
| Tg2(fli1:CAAX-EGFP) |
|
| 1 | (2) | |
| Tg2(fli1:DsRed) |
|
| 1 | Oh et al., 2020 | |
| Tg2(fli1:eng) |
|
| 1 | Lelièvre et al., 2023 | |
| Tg2(fli1:GAL4-Hsa.TEAD2-2A-mCherry) |
|
| 1 | Nagasawa-Masuda et al., 2017 | |
| Tg2(fli1:LIFEACT-EGFP) |
|
| 1 | (6) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-244H7 | ZFIN Curated Data | |
| Contains | STS | chunp30691 | ||
| Encodes | EST | cb855 | Thisse et al., 2001 | |
| Encodes | EST | fc45b11 | ||
| Encodes | cDNA | MGC:77011 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131348 (1) | 3050 nt | ||
| Genomic | GenBank:BX927076 (1) | 152951 nt | ||
| Polypeptide | UniProtKB:A0A8M9PLW9 (1) | 474 aa |
- Kondrychyn, I., He, L., Wint, H., Betsholtz, C., Phng, L.K. (2025) Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis. eLIFE. 13:
- Oh, C.K., Kim, M.S., Shin, U., Kang, J.W., Kim, Y.H., Ko, H.S., Ra, J.S., Ahn, S., Choi, E.Y., Yu, S., Nam, U., Choi, T., Myung, K., Lee, Y. (2025) SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish. Journal of Cellular Physiology. 240:e70023e70023
- Wang, C., Zhong, Y., Zhang, Y., Jiang, Y., Wang, C., An, L., Luo, C., Yang, L., He, Z., Yang, Y., Luo, M., Mao, M., Wang, W., Liu, Q., Shi, Y., Ping, Y.F. (2025) Cd248a regulates pericyte development and viability in zebrafish. Communications biology. 8:451451
- Yang, S., Zhang, X., Li, X., Li, H. (2025) Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation. Cellular and molecular life sciences : CMLS. 82:110110
- Zhou, W., Cai, W., Li, Y., Gao, L., Liu, X., Liu, S., Lei, J., Zhang, J., Wang, Y., Jiang, Z., Wu, X., Fan, X., Li, F., Zheng, L., Yuan, W. (2025) The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish. International Journal of Molecular Sciences. 26:
- Bowley, G., Irving, S., Hoefer, I., Wilkinson, R., Pasterkamp, G., Darwish, H.M.S., White, S., Francis, S.E., Chico, T., Noel, E., Serbanovic-Canic, J., Evans, P.C. (2024) Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports. 14:3013030130
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Chen, C., Qin, Y., Xu, Y., Wang, X., Lei, W., Shen, X., Chen, L., Wang, L., Gong, J., Wang, Y., Hu, S., Liu, D. (2024) Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia. Cardiovascular research. 120(9):1065-1080
- Goumenaki, P., Günther, S., Kikhi, K., Looso, M., Marín-Juez, R., Stainier, D.Y.R. (2024) The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration. Nature cardiovascular research. 3:115811761158-1176
- Lv, Y., Li, J., Yu, S., Zhang, Y., Hu, H., Sun, K., Jia, D., Han, Y., Tu, J., Huang, Y., Liu, X., Zhang, X., Gao, P., Chen, X., Shaw Williams, M.T., Tang, Z., Shu, X., Liu, M., Ren, X. (2024) The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. The Journal of biological chemistry. 300(3):105772
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