Gene
otx1
- ID
- ZDB-GENE-980526-400
- Name
- orthodenticle homeobox 1
- Symbol
- otx1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within inner ear morphogenesis; lateral semicircular canal development; and retinal pigment epithelium development. Predicted to be active in nucleus. Is expressed in several structures, including germ ring; immature eye; nervous system; neural keel; and presumptive neural plate. Orthologous to human OTX1 (orthodenticle homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 61 figures from 37 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb769 (22 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-otx1 | N/A | (2) |
| MO2-otx1 | N/A | (2) |
| MO3-otx1 | N/A | Foucher et al., 2006 |
| MO4-otx1 | N/A | Foucher et al., 2006 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Transcription factor Otx | Transcription factor Otx1 | Transcription factor Otx, C-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B2GNW8 | InterPro | 323 | ||||||
| UniProtKB:Q91994 | InterPro | 323 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1-LOXP-gata2a:EGFP-5HS4) |
|
| 3 | (2) | |
| Tg2(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1-LOXP-gata2a:EGFP-5HS4) |
|
| 3 | (2) | |
| Tg3(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1-LOXP-gata2a:EGFP-5HS4) |
|
| 3 | (2) | |
| TgBAC(otx1:GAL4-VP16,myl7:mCherry) |
|
| 1 | Förster et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-74F1 | ZFIN Curated Data | |
| Encodes | EST | cb769 | Thisse et al., 2001 | |
| Encodes | EST | fj99f05 | ||
| Encodes | cDNA | MGC:55275 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191298 | ZFIN Curated Data | |
| Has Artifact | EST | IMAGE:5612640 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131250 (1) | 2539 nt | ||
| Genomic | GenBank:BX649529 (2) | 216647 nt | ||
| Polypeptide | UniProtKB:B2GNW8 (1) | 323 aa |
- Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B. (2022) Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear. Developmental Biology. 492:139-153
- Micheloni, G., Carnovali, M., Millefanti, G., Rizzetto, M., Moretti, V., Montalbano, G., Acquati, F., Giaroni, C., Valli, R., Costantino, L., Ferrara, F., Banfi, G., Mariotti, M., Porta, G. (2021) Soy diet induces intestinal inflammation in adult Zebrafish: Role of OTX and P53 family. International journal of experimental pathology. 103(1):13-22
- Green, D.G., Whitener, A.E., Mohanty, S., Mistretta, B., Gunaratne, P., Yeh, A.T., Lekven, A.C. (2020) Wnt signaling regulates neural plate patterning in distinct temporal phases with dynamic transcriptional outputs. Developmental Biology. 462(2):152-164
- Kantarci, H., Gou, Y., Riley, B.B. (2020) The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle. eLIFE. 9:
- Kontur, C., Jeong, M., Cifuentes, D., Giraldez, A.J. (2020) Ythdf m6A Readers Function Redundantly during Zebrafish Development. Cell Reports. 33:108598
- Staudt, N., Giger, F.A., Fielding, T., Hutt, J.A., Foucher, I., Snowden, V., Hellich, A., Kiecker, C., Houart, C. (2019) Pineal progenitors originate from a non-neural territory limited by FGF signalling. Development (Cambridge, England). 146(22):
- Young, R.M., Hawkins, T.A., Cavodeassi, F., Stickney, H.L., Schwarz, Q., Lawrence, L.M., Wierzbicki, C., Cheng, B.Y., Luo, J., Ambrosio, E.M., Klosner, A., Sealy, I.M., Rowell, J., Trivedi, C.A., Bianco, I.H., Allende, M.L., Busch-Nentwich, E.M., Gestri, G., Wilson, S.W. (2019) Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification. eLIFE. 8:
- Dragojević, J., Mihaljević, I., Popović, M., Zaja, R., Smital, T. (2018) In vitro characterization of zebrafish (Danio rerio) organic anion transporters Oat2a-e. Toxicology in vitro : an international journal published in association with BIBRA. 46:246-256
- Gou, Y., Vemaraju, S., Sweet, E.M., Kwon, H.J., Riley, B.B. (2018) sox2 and sox3 play unique roles in development of hair cells and neurons in the zebrafish inner ear. Developmental Biology. 435(1):73-83
- Ladam, F., Stanney, W., Donaldson, I.J., Yildiz, O., Bobola, N., Sagerström, C.G. (2018) TALE factors use two distinct functional modes to control an essential zebrafish gene expression program. eLIFE. 7
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