Gene
apoeb
- ID
- ZDB-GENE-980526-368
- Name
- apolipoprotein Eb
- Symbol
- apoeb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including heparan sulfate proteoglycan binding activity; heparin binding activity; and low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including cholesterol efflux; phospholipid efflux; and triglyceride-rich lipoprotein particle clearance. Predicted to be located in extracellular matrix and extracellular space. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in several structures, including epidermis; fin bud; hematopoietic cell; median fin; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 92 figures from 57 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb82 (8 images)
- eu173 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Hu et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-apoeb | Höijer et al., 2022 | |
| CRISPR2-apoeb | (2) | |
| CRISPR3-apoeb | (3) | |
| CRISPR4-apoeb | Kroll et al., 2025 | |
| TALEN1-apoeb | (2) |
1 - 5 of 5
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 1 | Alliance | {?Macular degeneration, age-related} | 603075 |
| Alzheimer's disease 2 | Alliance | Alzheimer disease 2 | 104310 |
| Alzheimer's disease 3 | Alliance | {?Alzheimer disease, protection against, due to APOE3-Christchurch} | 607822 |
| hyperlipoproteinemia type III | Alliance | Hyperlipoproteinemia, type III | 617347 |
| hyperlipoproteinemia type III | Alliance | {Coronary artery disease, severe, susceptibility to} | 617347 |
1 - 5 of 7 Show all
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Apolipoprotein A1/A4/E | Apolipoprotein A/E |
|---|---|---|---|---|
| UniProtKB:O42364 | InterPro | 281 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(apoeb:LY-EGFP) |
|
| 1 | (28) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-7F3 | ZFIN Curated Data | |
| Encodes | EST | cb82 | Thisse et al., 2001 | |
| Encodes | EST | eu173 | Thisse et al., 2005 | |
| Encodes | EST | fa03d06 | ZFIN Curated Data | |
| Encodes | EST | fa97a11 | ZFIN Curated Data | |
| Encodes | EST | fc95h12 | ZFIN Curated Data | |
| Encodes | EST | fj54e06 | ZFIN Curated Data | |
| Encodes | EST | zeh1311 | ||
| Encodes | cDNA | MGC:56515 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77232 | ZFIN Curated Data |
1 - 10 of 12
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131098 (1) | 1345 nt | ||
| Genomic | GenBank:BX004983 (1) | 234489 nt | ||
| Polypeptide | UniProtKB:O42364 (1) | 281 aa |
- Kroll, F., Donnelly, J., Özcan, G.G., Mackay, E., Rihel, J. (2025) Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer's disease risk genes. eLIFE. 13:
- Li, X., Gao, X., Liu, S., Liu, S., Liu, Y., Gao, L., Xia, L., Liu, K., Jin, M. (2025) 2-Hydroxy-4-n-octyloxybenzophenone induces developmental neurotoxicity and multiple sclerosis-like symptoms through cacna1a regulated Ca2 + inward flow and microglial activation. Ecotoxicology and environmental safety. 295:118154118154
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Iyer, H., Talbot, W.S. (2024) Chloride transporter ClC-7 is essential for phagocytic clearance by microglia. Journal of Cell Science. 137(4):
- Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H. (2024) Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo. Journal of hazardous materials. 480:136215136215
- Song, G., Feng, G., Li, Q., Peng, J., Ge, W., Long, Y., Cui, Z. (2024) Transcriptomic Characterization of Key Factors and Signaling Pathways for the Regeneration of Partially Hepatectomized Liver in Zebrafish. International Journal of Molecular Sciences. 25(13):
- Zeng, T., Lv, J., Liang, J., Xie, B., Liu, L., Tan, Y., Zhu, J., Jiang, J., Xie, H. (2024) Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway. Frontiers in cell and developmental biology. 12:13813621381362
- Deng, Y., Han, X., Chen, H., Zhao, C., Chen, Y., Zhou, J., de The, H., Zhu, J., Yuan, H. (2023) Ypel5 regulates liver development and function in zebrafish. Journal of molecular cell biology. 15(3):
- Li, J., Li, Z., Zhu, Y., Peng, H., Du, Z., Ru, S., Wang, W. (2023) Bisphenol S remodels red blood cell membrane lipids by altering plasma lipid levels, causing the risk of venous thrombosis in SD rats and zebrafish embryos. Environment International. 182:108331108331
- Luo, G., Zeng, D., Liu, J., Li, D., Takiff, H.E., Song, S., Gao, Q., Yan, B. (2023) Temporal and cellular analysis of granuloma development in mycobacterial infected adult zebrafish. Journal of Leukocyte Biology. 115(3):525-535
1 - 10 of 137
Show