Gene
hoxa13b
- ID
- ZDB-GENE-980526-365
- Name
- homeobox A13b
- Symbol
- hoxa13b Nomenclature History
- Previous Names
-
- Hoxa-13
- wu:fa66g07
- zgc:110514
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within fin development and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including chondroblast; mesoderm; oocyte; pectoral fin; and tail bud. Human ortholog(s) of this gene implicated in Guttmacher syndrome and hand-foot-genital syndrome. Orthologous to human HOXA13 (homeobox A13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu282 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hoxa13b | (6) | |
| CRISPR2-hoxa13b | (2) | |
| CRISPR3-hoxa13b | (2) | |
| CRISPR4-hoxa13b | (3) | |
| CRISPR5-hoxa13b | Ye et al., 2021 | |
| MO1-hoxa13b | N/A | Crow et al., 2009 |
| MO2-hoxa13b | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Guttmacher syndrome | Alliance | ?Guttmacher syndrome | 176305 |
| hand-foot-genital syndrome | Alliance | Hand-foot-genital syndrome | 140000 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Anterior-posterior axis regulatory homeobox | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein Hox1A3 N-terminal | Homeodomain |
|---|---|---|---|---|---|---|---|
| UniProtKB:P79724 | InterPro | 289 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxa13b-201
(1)
|
Ensembl | 1,546 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hoxa13b-FLAG-2A-GFP) |
| 1 | (2) | ||
| Tg(hsp70l:hoxa13b-2A-mCherry,cryaa:mCherry) |
| 1 | (2) | ||
| Tg(hsp70l:hoxa13b-FLAG-2A-GFP) |
| 1 | (2) | ||
| Tg(hsp70l:hoxa13b-FLAG-2A-mCherry,cryaa:mCherry) |
| Zebrafish Nomenclature Committee |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-45E15 | ZFIN Curated Data | |
| Encodes | EST | eu282 | Thisse et al., 2005 | |
| Encodes | EST | fa66g07 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110514 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192624 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131194 (1) | 1542 nt | ||
| Genomic | GenBank:CR392024 (1) | 183486 nt | ||
| Polypeptide | UniProtKB:P79724 (1) | 289 aa |
- Cumplido, N., Arratia, G., Desvignes, T., Muñoz-Sánchez, S., Postlethwait, J.H., Allende, M.L. (2024) Hox genes control homocercal caudal fin development and evolution. Science advances. 10:eadj5991
- Ishizaka, M., Maeno, A., Nakazawa, H., Fujii, R., Oikawa, S., Tani, T., Kanno, H., Koita, R., Kawamura, A. (2024) The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development. Scientific Reports. 14:2360223602
- Tanaka, Y., Okayama, S., Urakawa, K., Kudoh, H., Ansai, S., Abe, G., Tamura, K. (2024) Fin elaboration via anterior-posterior constraint by hhip on Hedgehog signaling in teleosts. Development (Cambridge, England). 151(22):
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Weiss, J.M., Hunter, M.V., Cruz, N.M., Baggiolini, A., Tagore, M., Ma, Y., Misale, S., Marasco, M., Simon-Vermot, T., Campbell, N.R., Newell, F., Wilmott, J.S., Johansson, P.A., Thompson, J.F., Long, G.V., Pearson, J.V., Mann, G.J., Scolyer, R.A., Waddell, N., Montal, E.D., Huang, T.H., Jonsson, P., Donoghue, M.T.A., Harris, C.C., Taylor, B.S., Xu, T., Chaligné, R., Shliaha, P.V., Hendrickson, R., Jungbluth, A.A., Lezcano, C., Koche, R., Studer, L., Ariyan, C.E., Solit, D.B., Wolchok, J.D., Merghoub, T., Rosen, N., Hayward, N.K., White, R.M. (2022) Anatomic position determines oncogenic specificity in melanoma. Nature. 604(7905):354-361
- Xue, S., Ly, T.T.N., Vijayakar, R.S., Chen, J., Ng, J., Mathuru, A.S., Magdinier, F., Reversade, B. (2022) HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring. Nature communications. 13:3583
- Hawkins, M.B., Henke, K., Harris, M.P. (2021) Latent developmental potential to form limb-like skeletal structures in zebrafish. Cell. 184(4):899-911.e13
- Smeeton, J., Natarajan, N., Naveen Kumar, A., Miyashita, T., Baddam, P., Fabian, P., Graf, D., Crump, J.G. (2021) Zebrafish Model for Spondylo-Megaepiphyseal-Metaphyseal Dysplasia Reveals Post-Embryonic Roles of Nkx3.2 in the Skeleton. Development (Cambridge, England). 148(2):
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
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