Gene
ikzf1
- ID
- ZDB-GENE-980526-304
- Name
- IKAROS family zinc finger 1 (Ikaros)
- Symbol
- ikzf1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Predicted to be located in nucleus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; and common variable immunodeficiency 13. Orthologous to human IKZF1 (IKAROS family zinc finger 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 92 figures from 70 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu522 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
fr105 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
sa11269 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa22255 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa22256 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa31915 | Allele with one point mutation | Unknown | Splice Site | ENU | |
t24980 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
t25880 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
zf3330 | Allele with one MNV | Unknown | Premature Stop | CRISPR | |
zf3331 | Allele with one insertion | Unknown | Premature Stop | CRISPR |
1 - 9 of 9
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-ikzf1 | Huang et al., 2019 | |
CRISPR2-ikzf1 | Huang et al., 2019 | |
CRISPR3-ikzf1 | O'Meara et al., 2021 | |
CRISPR4-ikzf1 | (3) | |
CRISPR5-ikzf1 | (2) | |
MO1-ikzf1 | N/A | Schorpp et al., 2006 |
MO2-ikzf1 | N/A | Schorpp et al., 2006 |
TALEN1-ikzf1 | Moore et al., 2012 |
1 - 8 of 8
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
common variable immunodeficiency 13 | Alliance | Immunodeficiency, common variable, 13 | 616873 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Ikaros C2H2-type zinc-finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
---|---|---|---|---|---|
UniProtKB:A0A8M2B3C7 | InterPro | 641 | |||
UniProtKB:A0A8M2B3I1 | InterPro | 496 | |||
UniProtKB:O93581 | InterPro | 537 | |||
UniProtKB:A0A8M3AZ03 | InterPro | 599 | |||
UniProtKB:A0A8M2B2R4 | InterPro | 588 |
1 - 5 of 8 Show all
Interactions and Pathways
No data available
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
TgBAC(ikzf1:EGFP) |
|
| 1 | (26) | |
TgBAC(ikzf1:Eos) |
|
| 1 | (3) | |
Tg(coro1a:HA-ikzf1,cryaa:Cerulean) |
| 1 | Huang et al., 2019 |
1 - 3 of 3
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-57F7 | ZFIN Curated Data | |
Encodes | EST | eu522 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:193861 | ZFIN Curated Data |
1 - 3 of 3
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_130986 (1) | 2309 nt | ||
Genomic | GenBank:BX890571 (1) | 167315 nt | ||
Polypeptide | UniProtKB:A0A8M2B3C7 (1) | 641 aa |
- Sertori, R., Truong, B., Singh, M.K., Shinton, S., Price, R., Sharo, A., Shultes, P., Sunderam, U., Rana, S., Srinivasan, R., Datta, S., Font-Burgada, J., Brenner, S.E., Puck, J.M., Wiest, D.L. (2025) Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia. Frontiers in immunology. 16:15398481539848
- Jing, R., Falchetti, M., Han, T., Najia, M., Hensch, L.T., Meader, E., Lummertz da Rocha, E., Kononov, M., Wang, S., Bingham, T., Li, Z., Zhao, Y., Frenis, K., Kubaczka, C., Yang, S., Jha, D., Rodrigues-Luiz, G.F., Rowe, R.G., Schlaeger, T.M., Maus, M.V., North, T.E., Zon, L.I., Daley, G.Q. (2024) Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP. Cell Stem Cell. 32(1):71-85.e5
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Liu, S., Feng, Z., Su, M., Liu, C., Xi, Y., Chen, H., Luo, L., Tian, X., Zhao, F., Li, L. (2024) Tango6 regulates HSPC proliferation and definitive haematopoiesis via Ikzf1 and Cmyb in caudal haematopoietic tissue. Development (Cambridge, England). 152(1):
- Peterson, E.A., Sun, J., Chen, X., Wang, J. (2024) Neutrophils facilitate the epicardial regenerative response after zebrafish heart injury. Developmental Biology. 508:93-106
- Sobah, M.L., Liongue, C., Ward, A.C. (2024) Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities. Journal of Innate Immunity. 16(1):262-282
- Al Qaryoute, A., Fallatah, W., Dhinoja, S., Raman, R., Jagadeeswaran, P. (2023) Role of microRNAs and their downstream target transcription factors in zebrafish thrombopoiesis. Scientific Reports. 13:1606616066
- Allers, M., Bakker, P.A., Hoeksma, J., Spaink, H.P., den Hertog, J. (2023) Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae. Disease models & mechanisms. 16(2):
- Heidary, S., Awasthi, N., Page, N., Allnutt, T., Lewis, R.S., Liongue, C., Ward, A.C. (2023) A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1). Cellular and molecular life sciences : CMLS. 80:109109
- Rothschild, S.C., Lai, G., Tombes, R.M., Clements, W.K. (2023) Constitutively active CaMKII Drives B lineage acute lymphoblastic leukemia/lymphoma in tp53 mutant zebrafish. PLoS Genetics. 19:e1011102e1011102
1 - 10 of 136
Show