Gene

ikzf1

ID
ZDB-GENE-980526-304
Name
IKAROS family zinc finger 1 (Ikaros)
Symbol
ikzf1 Nomenclature History
Previous Names
  • ikaros (1)
  • znfn1a1 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Predicted to be located in nucleus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; and common variable immunodeficiency 13. Orthologous to human IKZF1 (IKAROS family zinc finger 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
92 figures from 70 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
fr105Allele with one deletionUnknownPremature StopCRISPR
sa11269Allele with one point mutationUnknownPremature StopENU
sa22255Allele with one point mutationUnknownPremature StopENU
sa22256Allele with one point mutationUnknownPremature StopENU
sa31915Allele with one point mutationUnknownSplice SiteENU
t24980Allele with one point mutationUnknownPremature StopENU
t25880Allele with one point mutationUnknownPremature StopENU
zf3330Allele with one MNVUnknownPremature StopCRISPR
zf3331Allele with one insertionUnknownPremature StopCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With ikzf1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
common variable immunodeficiency 13 Alliance Immunodeficiency, common variable, 13 616873
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Associated With ikzf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Family IPR050589 Ikaros C2H2-type zinc-finger
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
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Domain Details Per Protein
Protein Additional Resources Length Ikaros C2H2-type zinc-finger Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:A0A8M2B3C7 InterPro 641
UniProtKB:A0A8M2B3I1 InterPro 496
UniProtKB:O93581 InterPro 537
UniProtKB:A0A8M3AZ03 InterPro 599
UniProtKB:A0A8M2B2R4 InterPro 588
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 13
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ikzf1-201 (1) Ensembl 2,301 nt
mRNA ikzf1-202 (1) Ensembl 1,219 nt
mRNA ikzf1-203 (1) Ensembl 1,513 nt
mRNA ikzf1-204 (1) Ensembl 1,639 nt
mRNA ikzf1-205 (1) Ensembl 1,915 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
TgBAC(ikzf1:EGFP)
  • ikzf1
  • Danio rerio
1 (26)
TgBAC(ikzf1:Eos)
  • ikzf1
  • Danio rerio
1 (3)
Tg(coro1a:HA-ikzf1,cryaa:Cerulean)
  • Danio rerio
1Huang et al., 2019
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-57F7ZFIN Curated Data
EncodesESTeu522Thisse et al., 2005
EncodescDNAMGC:193861ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanIKZF17
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
MouseIkzf111
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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