Gene
gata2a
- ID
- ZDB-GENE-980526-260
- Name
- GATA binding protein 2a
- Symbol
- gata2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within circulatory system development; hemopoiesis; and ventral spinal cord interneuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; presumptive structure; and trunk vasculature. Human ortholog(s) of this gene implicated in acute myeloid leukemia; depressive disorder; immunodeficiency 21; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 179 figures from 127 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu473 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
1 - 10 of 13
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | {Leukemia, acute myeloid, susceptibility to} | 601626 |
| immunodeficiency 21 | Alliance | Immunodeficiency 21 | 614172 |
| myelodysplastic syndrome | Alliance | {Myelodysplastic syndrome, susceptibility to} | 614286 |
| Emberger syndrome | 614038 |
1 - 4 of 4
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription factor GATA | Transcription factor, GATA-2/3 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q709 | InterPro | 397 | ||||
| UniProtKB:Q7T3G1 | InterPro | 456 | ||||
| UniProtKB:A0A8M3AXB8 | InterPro | 460 | ||||
| UniProtKB:A0AB32U358 | InterPro | 393 |
1 - 4 of 4
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gata2a-201
(1)
|
Ensembl | 2,829 nt | ||
| mRNA |
gata2a-202
(1)
|
Ensembl | 2,533 nt | ||
| mRNA |
gata2a-203
(1)
|
Ensembl | 781 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Et(gata2a:EGFP) |
|
| 17 | (78) | |
| Tg(-7.3gata2a:GFP) |
|
| 1 | (23) | |
| Et1(gata2a:EGFP) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Et1(gata2a:GAL4-VP16) |
|
| 1 | (3) | |
| Et2(gata2a:EGFP) |
|
| 2 | (4) | |
| Et2(gata2a:GAL4-VP16) |
|
| 1 | (2) | |
| Et(-26.5Hsa.WT1-gata2a:EGFP) |
|
| 1 | (5) | |
| Et(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-Hsa.WT1-LOXP-gata2a:EGFP-5HS4) |
|
| 1 | (8) | |
| Et(gata2a:GAL4-VP16) |
|
| 1 | (2) | |
| Et(gata2a:YFP) |
|
| 145 | (20) |
1 - 10 of 464
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-63I20 | ZFIN Curated Data | |
| Encodes | EST | eu473 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:63885 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131233 (1) | 2571 nt | ||
| Genomic | GenBank:AL928619 (1) | 158847 nt | ||
| Polypeptide | UniProtKB:A0A8M3AXB8 (1) | 460 aa |
- Mai, J., Yang, L., Wang, M., Deng, J.M., Min, M., Xie, H.J., Jiang, Y.M., Sun, H.Q., Liu, X.J. (2025) Elevated Serum Homocysteine Levels Impair Embryonic Neurodevelopment by Dysregulating the Heat Shock Proteins. Developmental Neurobiology. 85:e22958e22958
- Bell, J.M., Turner, E.M., Biesemeyer, C., Vanderbeck, M.M., Hendricks, R., McGraw, H.F. (2024) foxg1a is required for hair cell development and regeneration in the zebrafish lateral line. Biology Open. 13(9):
- D'haene, E., López-Soriano, V., Martínez-García, P.M., Kalayanamontri, S., Rey, A.D., Sousa-Ortega, A., Naranjo, S., Van de Sompele, S., Vantomme, L., Mahieu, Q., Vergult, S., Neto, A., Gómez-Skarmeta, J.L., Martínez-Morales, J.R., Bauwens, M., Tena, J.J., De Baere, E. (2024) Comparative 3D genome analysis between neural retina and retinal pigment epithelium reveals differential cis-regulatory interactions at retinal disease loci. Genome biology. 25:123123
- Li, G., Sun, Y., Kwok, I., Yang, L., Wen, W., Huang, P., Wu, M., Li, J., Huang, Z., Liu, Z., He, S., Peng, W., Bei, J.X., Ginhoux, F., Ng, L.G., Zhang, Y. (2024) Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish. Nature communications. 15:811811
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Grimm, L., Mason, E., Yu, H., Dudczig, S., Panara, V., Chen, T., Bower, N.I., Paterson, S., Rondon Galeano, M., Kobayashi, S., Senabouth, A., Lagendijk, A.K., Powell, J., Smith, K.A., Okuda, K.S., Koltowska, K., Hogan, B.M. (2023) Single-cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development. The EMBO journal. 42(11):e112590
- Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
1 - 10 of 362
Show